NMR structure of FKBP12-mTOR FRB domain-rapamycin complex structure determined based on PCS
GVQVETISPG DGRTFPKRGQ TCVVHYTGML EDGKKFDSSR DRNKPFKFML GKQEVIRGWE EGVAQMSVGQ RAKLTISPDY AYGATGHPGI IPPHATLVFD VELLKLE
VAILWHEMWH EGLEEASRLY FGERNVKGMF EVLEPLHAMM ERGPQTLKET SFNQAYGRDL MEAQEWCRKY MKSGNVKDLT QAWDLYYHVF RRIS
Polymer type: polypeptide(L)
Total | 1H | 13C | 15N | |
---|---|---|---|---|
All | 59.2 % (1421 of 2400) | 53.9 % (677 of 1255) | 59.1 % (553 of 935) | 91.0 % (191 of 210) |
Backbone | 76.3 % (907 of 1188) | 72.8 % (300 of 412) | 72.4 % (423 of 584) | 95.8 % (184 of 192) |
Sidechain | 46.6 % (649 of 1394) | 44.1 % (372 of 843) | 50.7 % (270 of 533) | 38.9 % (7 of 18) |
Aromatic | 9.9 % (24 of 242) | 11.6 % (14 of 121) | 7.8 % (9 of 116) | 20.0 % (1 of 5) |
Methyl | 58.4 % (111 of 190) | 57.9 % (55 of 95) | 58.9 % (56 of 95) |
1. entity 1
GVQVETISPG DGRTFPKRGQ TCVVHYTGML EDGKKFDSSR DRNKPFKFML GKQEVIRGWE EGVAQMSVGQ RAKLTISPDY AYGATGHPGI IPPHATLVFD VELLKLE2. entity 2
VAILWHEMWH EGLEEASRLY FGERNVKGMF EVLEPLHAMM ERGPQTLKET SFNQAYGRDL MEAQEWCRKY MKSGNVKDLT QAWDLYYHVF RRISSolvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 298 K, pH 7
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
1 | FKBP12 | natural abundance | protein | 0.3 mM |
2 | FRB | [U-98% 15N] | protein | 0.3 mM |
3 | H2O | solvent | 90 % | |
4 | D2O | solvent | 10 % |