BMRB: 17876

STRUCTURAL AND FUNCTIONAL ANALYSIS OF A NOVEL POTASSIUM TOXI ARGENTINEAN SCORPION TITYUS TRIVITTATUS REVEALS A NEW KAPPA SUB-FAMILY

Authors

Saucedo-Yanez, A., Del Rio-Portilla, F., Hernandez-Lopez, R.

Assembly

Novel Toxin from De Venom of the Scorpion Tityus

Entity

1. Novel Toxin from De Venom of the Scorpion Tityus (polymer, Thiol state: not reported), 30 monomers, 3329.878 Da Detail

GSGCMPEYCA GQCRGKVSQD YCLKNCRCIR

Formula weight

3329.878 Da

Source organism

Tityus trivittatus

Exptl. method

solution NMR

Refine. method

TORSION ANGLE DYNAMICS, MOLECULAR DYNAMICS

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 100.0 %, Completeness: 96.0 %, Completeness (bb): 98.4 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	96.0 % (168 of 175)	96.0 % (168 of 175)
Backbone	98.4 % (62 of 63)	98.4 % (62 of 63)
Sidechain	94.6 % (106 of 112)	94.6 % (106 of 112)
Aromatic	100.0 % (8 of 8)	100.0 % (8 of 8)
Methyl	100.0 % (7 of 7)	100.0 % (7 of 7)

1. KAPPA-KTX3.1 SCORPION TOXIN

GSGCMPEYCA GQCRGKVSQD YCLKNCRCIR

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Sample

Solvent system 95% H2O/5% D2O, Pressure 1 atm, Temperature 298 K, pH 3.5, Details 2.3 mM K-KTX3.1 95% H2O/5% D2O

#	Name	Isotope labeling	Type	Concentration
1	KAPPA-KTX3.1 SCORPION TOXIN	natural abundance		2.3 mM
2	H2O	natural abundance		95 %
3	D2O	natural abundance		5 %

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Protein Blocks Logo

Calculated from 20 models in PDB: 2LI3, Strand ID: A Detail

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Release date

2012-01-11

Citation

New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing
Saucedo, A., Flores-Solis, D., Rodriguez de la Vega, R.C., Ramirez-Cordero, B., Hernandez-Lopez, R., Cano-Sanchez, P., Noriega-Navarro, R., Garcia-Valdes, J., Coronas-Valderrama, F., de Roodt, A., Brieba, L.G., Possani, L., Del Rio-Portilla, F.
J. Biol. Chem. (2012), 287, 12321-12330, PubMed 22238341 , DOI 10.1074/jbc.M111.329607 , Abstract

Related entities 1. Novel Toxin from De Venom of the Scorpion Tityus, : 1 : 1 : 5 entities Detail

Experiments performed 3 experiments Detail

Chemical shift validation 3 contents Detail