A novel 4/7-conotoxin LvIA from Conus lividus that selectively blocks 32 vs. 6/323 nicotinic acetylcholine receptors
ID | Type | Value order | Atom ID 1 | Atom ID 2 |
---|---|---|---|---|
1 | disulfide | sing | 1:CYS2:SG | 1:CYS8:SG |
2 | disulfide | sing | 1:CYS3:SG | 1:CYS16:SG |
Polymer type: polypeptide(L)
Total | 1H | 13C | |
---|---|---|---|
All | 80.1 % (113 of 141) | 90.0 % (72 of 80) | 67.2 % (41 of 61) |
Backbone | 78.2 % (61 of 78) | 93.5 % (29 of 31) | 68.1 % (32 of 47) |
Sidechain | 85.9 % (67 of 78) | 87.8 % (43 of 49) | 82.8 % (24 of 29) |
Aromatic | 0.0 % (0 of 8) | 0.0 % (0 of 4) | 0.0 % (0 of 4) |
Methyl | 90.0 % (9 of 10) | 100.0 % (5 of 5) | 80.0 % (4 of 5) |
1. entity
GCCSHPACNV DHPEICSolvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 297.5 (±17.5) K, pH 4
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
1 | Novel 4/7-Conotoxin LvIA | natural abundance | 1.5 mM | |
2 | H2O | natural abundance | 90 % | |
3 | D2O | natural abundance | 10 % |