The structural and functional effects of the Familial Hypertrophic Cardiomyopathy-linked cardiac troponin C mutation, L29Q
ID | Type | Value order | Atom ID 1 | Atom ID 2 |
---|---|---|---|---|
1 | na | sing | 1:ASP65:OD1 | 2:CA1:CA |
2 | na | sing | 1:ASP67:OD1 | 2:CA1:CA |
3 | na | sing | 1:SER69:OG | 2:CA1:CA |
4 | na | sing | 1:THR71:O | 2:CA1:CA |
5 | na | sing | 1:GLU76:OE1 | 2:CA1:CA |
6 | na | sing | 1:GLU76:OE2 | 2:CA1:CA |
Polymer type: polypeptide(L)
Total | 1H | 13C | 15N | |
---|---|---|---|---|
All | 84.4 % (857 of 1015) | 88.7 % (469 of 529) | 75.5 % (296 of 392) | 97.9 % (92 of 94) |
Backbone | 85.1 % (451 of 530) | 98.9 % (180 of 182) | 70.9 % (185 of 261) | 98.9 % (86 of 87) |
Sidechain | 86.1 % (489 of 568) | 83.3 % (289 of 347) | 90.7 % (194 of 214) | 85.7 % (6 of 7) |
Aromatic | 51.7 % (30 of 58) | 62.1 % (18 of 29) | 41.4 % (12 of 29) | |
Methyl | 97.6 % (80 of 82) | 97.6 % (40 of 41) | 97.6 % (40 of 41) |
1. entity 1
MDDIYKAAVE QLTEEQKNEF KAAFDIFVQG AEDGSISTKE LGKVMRMLGQ NPTPEELQEM IDEVDEDGSG TVDFDEFLVM MVRSMKDDSSolvent system 95% H2O/5% D2O, Pressure 1 atm, Temperature 303 K, pH 6.7
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
1 | entity_1 | [U-95% 13C; U-95% 15N] | protein | 0.3 ~ 0.4 mM |
2 | H2O | natural abundance | solvent | 95 % |
3 | D2O | [U-2H] | solvent | 5 % |