Structures of REV1 UBM2 domain complex with ubiquitin and with the first small-molecule that inhibits the REV1 UBM2-ubiquitin interaction
Polymer type: polypeptide(L)
Total | 1H | 13C | 15N | |
---|---|---|---|---|
All | 29.1 % (232 of 798) | 27.8 % (115 of 413) | 19.4 % (60 of 310) | 76.0 % (57 of 75) |
Backbone | 49.5 % (210 of 424) | 65.5 % (95 of 145) | 27.5 % (58 of 211) | 83.8 % (57 of 68) |
Sidechain | 5.0 % (22 of 441) | 7.5 % (20 of 268) | 1.2 % (2 of 166) | 0.0 % (0 of 7) |
Aromatic | 0.0 % (0 of 60) | 0.0 % (0 of 30) | 0.0 % (0 of 30) | |
Methyl | 6.9 % (5 of 72) | 8.3 % (3 of 36) | 5.6 % (2 of 36) |
1. entity 1
MGSSHHHHHH HHLNGSSLVP RGSIKSSGLE SNSDAGINLI ALPAFSQVDP EVFAALPAEL QRELKAAYDQ RQSolvent system 90% H2O/10% D2O, Pressure 1 mbar, Temperature 298 K, pH 7.0, Details 0.5 mM [U-13C; U-15N] REV1 UBM2, 90% H2O/10% D2O
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
1 | REV1 UBM2 | [U-13C; U-15N] | 0.5 mM |
Solvent system 90% H2O/10% D2O, Pressure 1 mbar, Temperature 298 K, pH 7.0, Details 0.5 mM [U-99% 15N] REV1 UBM2, 90% H2O/10% D2O
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
2 | REV1 UBM2 | [U-99% 15N] | 0.5 mM |