In response to the declaration of global pandemic of Coronavirus infectious disease 2019 (COVID-19) caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we provide comprehensive content on Coronavirus molecular structures and its interactions:
SARS-CoV-2 Envelope Protein Transmembrane Domain: Pentameric Structure Determined by Solid-State NMR
Polymer type: polypeptide(L)
Total | 13C | 15N | |
---|---|---|---|
All | 82.1 % (156 of 190) | 81.5 % (128 of 157) | 84.8 % (28 of 33) |
Backbone | 91.1 % (112 of 123) | 92.4 % (85 of 92) | 87.1 % (27 of 31) |
Sidechain | 74.2 % (72 of 97) | 74.7 % (71 of 95) | 50.0 % (1 of 2) |
Aromatic | 0.0 % (0 of 15) | 0.0 % (0 of 15) | |
Methyl | 87.2 % (34 of 39) | 87.2 % (34 of 39) |
1. entity 1
ETGTLIVNSV LLFLAFVVFL LVTLAILTAL RSolvent system aqueous buffer, Pressure 1 atm, Temperature 293 K, pH 7.5 (±0.2), Details 0.1 mg/uL [U-13C; U-15N] SARS-CoV-2 Envelope Protein Transmembrane Domain, 0.23 mg/uL POPC, 0.1 mg/uL POPE, 0.08 mg/uL bovine PI, 0.04 mg/uL POPS, 0.04 mg/uL Cholesterol, aqueous buffer.
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
1 | SARS-CoV-2 Envelope Protein Transmembrane Domain | [U-13C; U-15N] | 0.1 mg/uL | |
2 | POPC | natural abundance | 0.23 mg/uL | |
3 | POPE | natural abundance | 0.1 mg/uL | |
4 | bovine PI | natural abundance | 0.08 mg/uL | |
5 | POPS | natural abundance | 0.04 mg/uL | |
6 | Cholesterol | natural abundance | 0.04 mg/uL |
Solvent system aqueous buffer, Pressure 1 atm, Temperature 293 K, pH 7.5 (±0.2), Details 0.1 mg/uL [U-13C; U-15N] SARS-CoV-2 Envelope Protein Transmembrane Domain, 0.1 mg/uL [4-19F-Phe] fluoro SARS-CoV-2 Envelope Protein Transmembrane Domain, 0.23 mg/uL POPC, 0.1 mg/uL POPE, 0.08 mg/uL bovine PI, 0.04 mg/uL POPS, 0.04 mg/uL Cholesterol, aqueous buffer.
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
7 | SARS-CoV-2 Envelope Protein Transmembrane Domain | [U-13C; U-15N] | 0.1 mg/uL | |
8 | POPC | natural abundance | 0.23 mg/uL | |
9 | POPE | natural abundance | 0.1 mg/uL | |
10 | bovine PI | natural abundance | 0.08 mg/uL | |
11 | POPS | natural abundance | 0.04 mg/uL | |
12 | Cholesterol | natural abundance | 0.04 mg/uL | |
13 | fluoro SARS-CoV-2 Envelope Protein Transmembrane Domain | [4-19F-Phe] | 0.1 mg/uL |
Solvent system aqueous buffer, Pressure 1 atm, Temperature 293 K, pH 7.5 (±0.2), Details 0.1 mg/uL [U-15N] 15N SARS-CoV-2 Envelope Protein Transmembrane Domain, 0.1 mg/uL [U-13C] 13C SARS-CoV-2 Envelope Protein Transmembrane Domain, 0.23 mg/uL POPC, 0.1 mg/uL POPE, 0.08 mg/uL bovine PI, 0.04 mg/uL POPS, 0.04 mg/uL Cholesterol, aqueous buffer.
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
14 | POPC | natural abundance | 0.23 mg/uL | |
15 | POPE | natural abundance | 0.1 mg/uL | |
16 | bovine PI | natural abundance | 0.08 mg/uL | |
17 | POPS | natural abundance | 0.04 mg/uL | |
18 | Cholesterol | natural abundance | 0.04 mg/uL | |
19 | 15N SARS-CoV-2 Envelope Protein Transmembrane Domain | [U-15N] | 0.1 mg/uL | |
20 | 13C SARS-CoV-2 Envelope Protein Transmembrane Domain | [U-13C] | 0.1 mg/uL |