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Solution NMR Structure of [Ala19]Crp4
Authors
Conibear, A.C., Rosengren, K.J.
Assembly
Alpha-defensin 4
Entity
1. Alpha-defensin 4 (polymer, Thiol state: all disulfide bound), 32 monomers, 3775.554 Da Detail

GLLCYCRKGH CKRGERVRAT CGIRFLYCCP RR


Formula weight
3775.554 Da
Entity Connection
disulfide 3 Detail

IDTypeValue orderAtom ID 1Atom ID 2
1disulfidesing1:CYS4:SG1:CYS29:SG
2disulfidesing1:CYS6:SG1:CYS21:SG
3disulfidesing1:CYS11:SG1:CYS28:SG

Source organism
Mus musculus
Exptl. method
solution NMR
Data set
assigned_chemical_shifts
Chemcal Shifts
1H: 226, 13C: 98, 15N: 30 assignments Detail
IDEntity IDSeq IDComp IDAtom IDAtom typeValVal errAmbig. code
111GLYHA2H3.8400.000
211GLYHA3H3.8400.000
311GLYCAC42.9180.000
412LEUHH8.5160.000
512LEUHAH4.3560.000
612LEUHB2H1.5840.000
712LEUHB3H1.5370.000
812LEUHGH1.5280.000
912LEUHD11H0.9020.002
1012LEUHD12H0.9020.002
1112LEUHD13H0.9020.002
1212LEUHD21H0.8670.002
1312LEUHD22H0.8670.002
1412LEUHD23H0.8670.002
1512LEUCAC54.8930.000
1612LEUCBC42.8220.000
1712LEUCGC26.5360.000
1812LEUCD1C24.7590.000
1912LEUCD2C23.7290.000
2012LEUNN121.7110.000
2113LEUHH8.2700.000
2213LEUHAH4.2640.000
2313LEUHB2H1.5210.000
2413LEUHB3H1.4550.002
2513LEUHGH1.4500.002
2613LEUHD11H0.8700.002
2713LEUHD12H0.8700.002
2813LEUHD13H0.8700.002
2913LEUHD21H0.8200.002
3013LEUHD22H0.8200.002
3113LEUHD23H0.8200.002
3213LEUCAC54.7450.000
3313LEUCBC42.1340.000
3413LEUCGC26.7420.000
3513LEUCD1C24.4950.000
3613LEUCD2C23.7470.000
3713LEUNN124.6060.000
3814CYSHH7.5800.000
3914CYSHAH5.0610.000
4014CYSHB2H2.6930.004
4114CYSHB3H1.6110.000
4214CYSCAC55.4320.000
4314CYSCBC48.4330.022
4414CYSNN118.3240.000
4515TYRHH8.6900.000
4615TYRHAH4.5530.002
4715TYRHB2H2.9210.003
4815TYRHB3H2.3740.003
4915TYRHD1H7.0190.000
5015TYRHD2H7.0190.000
5115TYRHE1H6.7130.000
5215TYRHE2H6.7130.000
5315TYRCAC56.9780.000
5415TYRCBC42.4940.000
5515TYRNN117.5600.000
5616CYSHH9.2480.000
5716CYSHAH5.5970.000
5816CYSHB2H3.1390.002
5916CYSHB3H3.0850.002
6016CYSCAC55.4440.000
6116CYSCBC41.0120.000
6216CYSNN123.7860.000
6317ARGHH10.0180.000
6417ARGHAH4.7680.000
6517ARGHB2H1.7520.000
6617ARGHB3H1.6300.000
6717ARGHG2H1.6930.002
6817ARGHG3H1.4640.002
6917ARGHD2H3.2350.002
7017ARGHD3H3.2350.002
7117ARGHEH9.6330.001
7217ARGCAC55.2110.000
7317ARGCBC32.9700.000
7417ARGCGC26.8880.003
7517ARGCDC46.2120.000
7617ARGNN128.7750.000
7717ARGNEN124.6970.000
7818LYSHH8.6230.001
7918LYSHAH3.5830.000
8018LYSHB2H1.5150.002
8118LYSHB3H1.1890.002
8218LYSHG2H0.9290.001
8318LYSHG3H0.8870.001
8418LYSHD2H1.4690.002
8518LYSHD3H1.4690.002
8618LYSHE2H2.8400.000
8718LYSHE3H2.8400.000
8818LYSCAC56.1970.000
8918LYSCBC32.4770.000
9018LYSCGC24.6160.000
9118LYSCDC28.9740.000
9218LYSCEC41.7300.000
9318LYSNN122.8030.000
9419GLYHH8.7840.000
9519GLYHA2H3.3750.001
9619GLYHA3H4.2180.002
9719GLYCAC47.5960.013
9819GLYNN115.9580.000
99110HISHH8.0590.000
100110HISHAH4.6320.000
101110HISHB2H3.3500.000
102110HISHB3H3.0940.000
103110HISHD2H7.2620.002
104110HISHE1H8.5500.000
105110HISCAC54.9690.000
106110HISCBC31.2660.000
107110HISNN117.1230.000
108111CYSHH8.8540.000
109111CYSHAH5.0230.008
110111CYSHB2H3.7280.001
111111CYSHB3H2.6380.000
112111CYSCAC52.0880.000
113111CYSCBC36.7810.000
114111CYSNN117.4510.000
115112LYSHH8.5480.000
116112LYSHAH4.3960.000
117112LYSHB2H1.9020.002
118112LYSHB3H1.3510.002
119112LYSHG2H1.3300.002
120112LYSHG3H1.3300.002
121112LYSHD2H1.5430.002
122112LYSHD3H1.5430.002
123112LYSHE2H2.8420.001
124112LYSHE3H2.8420.001
125112LYSCAC56.1120.000
126112LYSCBC33.3830.000
127112LYSCGC25.7940.000
128112LYSCDC28.9880.000
129112LYSCEC41.7140.000
130112LYSNN120.5460.000
131113ARGHH8.5070.000
132113ARGHAH4.0890.000
133113ARGHB2H1.8280.002
134113ARGHB3H1.7390.002
135113ARGHG2H1.6230.002
136113ARGHG3H1.6230.002
137113ARGHD2H3.2100.001
138113ARGHD3H3.2100.001
139113ARGHEH7.1940.000
140113ARGCAC58.3550.000
141113ARGCBC29.5640.000
142113ARGCGC26.9070.000
143113ARGCDC43.1220.000
144113ARGNN121.5290.000
145114GLYHH8.9220.000
146114GLYHA2H3.8140.001
147114GLYHA3H4.2030.001
148114GLYCAC45.0410.000
149114GLYNN112.2440.000
150115GLUHH7.8110.000
151115GLUHAH4.8430.000
152115GLUHB2H2.4620.000
153115GLUHB3H1.6090.000
154115GLUHG2H2.0420.000
155115GLUHG3H1.8600.000
156115GLUCAC54.2000.000
157115GLUCBC30.0420.000
158115GLUCGC35.9330.000
159115GLUNN118.0700.000
160116ARGHH9.0870.000
161116ARGHAH4.7410.000
162116ARGHB2H1.7130.000
163116ARGHB3H1.7130.000
164116ARGHG2H1.5300.000
165116ARGHG3H1.5300.000
166116ARGHD2H3.1700.003
167116ARGHD3H3.1700.003
168116ARGHEH7.2080.000
169116ARGCAC53.5540.000
170116ARGCBC33.3980.000
171116ARGCGC26.7520.000
172116ARGCDC43.5430.000
173116ARGNN118.9430.000
174117VALHH8.7580.000
175117VALHAH4.1880.000
176117VALHBH2.1180.007
177117VALHG11H1.1570.002
178117VALHG12H1.1570.002
179117VALHG13H1.1570.002
180117VALHG21H0.9880.002
181117VALHG22H0.9880.002
182117VALHG23H0.9880.002
183117VALCAC63.1400.000
184117VALCBC32.1140.000
185117VALCG1C23.3880.000
186117VALCG2C21.4840.000
187117VALNN124.4780.000
188118ARGHH9.3830.000
189118ARGHAH4.6210.007
190118ARGHB2H2.0500.002
191118ARGHB3H1.7540.000
192118ARGHG2H1.7340.002
193118ARGHG3H1.7340.002
194118ARGHD2H3.2800.001
195118ARGHD3H3.2320.002
196118ARGHEH7.2960.001
197118ARGCAC55.5270.000
198118ARGCBC32.6890.000
199118ARGCGC26.9270.000
200118ARGCDC42.6540.000
201118ARGNN128.2650.000
202119ALAHH8.1750.001
203119ALAHAH4.6730.002
204119ALAHB1H1.5870.010
205119ALAHB2H1.5870.010
206119ALAHB3H1.5870.010
207119ALACAC51.4670.000
208119ALACBC20.6890.000
209119ALANN119.0890.000
210120THRHH8.2480.000
211120THRHAH4.9590.000
212120THRHBH4.4840.000
213120THRHG21H1.2870.002
214120THRHG22H1.2870.002
215120THRHG23H1.2870.002
216120THRCAC61.3330.000
217120THRCBC70.3730.000
218120THRCG2C21.6540.000
219120THRNN111.1150.000
220121CYSHH8.1660.000
221121CYSHAH4.9060.000
222121CYSHB2H3.2870.004
223121CYSHB3H3.2440.008
224121CYSCAC54.7980.000
225121CYSCBC42.5760.000
226121CYSNN117.5600.000
227122GLYHH8.2890.000
228122GLYHA2H3.7780.000
229122GLYHA3H3.9450.000
230122GLYCAC45.1560.000
231122GLYNN109.3670.000
232123ILEHH8.3330.000
233123ILEHAH4.0210.000
234123ILEHBH1.8730.001
235123ILEHG12H1.4980.002
236123ILEHG13H1.1690.002
237123ILEHG21H0.9040.002
238123ILEHG22H0.9040.002
239123ILEHG23H0.9040.002
240123ILEHD11H0.8490.001
241123ILEHD12H0.8490.001
242123ILEHD13H0.8490.001
243123ILECAC62.2260.000
244123ILECBC36.6830.000
245123ILECG1C27.2250.000
246123ILECG2C17.3970.000
247123ILECD1C12.1910.000
248123ILENN121.9660.000
249124ARGHH8.5400.000
250124ARGHAH3.9910.000
251124ARGHB2H1.9080.000
252124ARGHB3H1.9080.000
253124ARGHG2H1.5410.000
254124ARGHG3H1.5410.000
255124ARGHD2H3.2140.000
256124ARGHD3H3.1610.005
257124ARGHEH7.2300.000
258124ARGCAC57.3510.000
259124ARGCBC28.3780.000
260124ARGCGC27.7800.000
261124ARGCDC43.1940.000
262124ARGNN118.8340.000
263125PHEHH7.8370.000
264125PHEHAH5.1210.004
265125PHEHB2H3.0820.000
266125PHEHB3H2.7250.003
267125PHEHD1H7.1500.000
268125PHEHD2H7.1500.000
269125PHEHE1H7.3650.000
270125PHEHE2H7.3650.000
271125PHEHZH7.3320.000
272125PHECAC55.9950.000
273125PHECBC41.2120.000
274125PHENN118.2520.000
275126LEUHH9.3530.000
276126LEUHAH4.7100.000
277126LEUHB2H1.6390.004
278126LEUHB3H1.5960.007
279126LEUHGH1.3890.004
280126LEUHD11H0.8380.002
281126LEUHD12H0.8380.002
282126LEUHD13H0.8380.002
283126LEUHD21H0.7990.001
284126LEUHD22H0.7990.001
285126LEUHD23H0.7990.001
286126LEUCAC53.9270.000
287126LEUCBC44.7220.000
288126LEUCGC26.8840.000
289126LEUCD1C23.3130.000
290126LEUCD2C25.2010.000
291126LEUNN123.5310.000
292127TYRHH8.9520.000
293127TYRHAH5.0330.000
294127TYRHB2H2.9680.003
295127TYRHB3H2.2840.006
296127TYRHD1H6.8900.000
297127TYRHD2H6.8900.000
298127TYRHE1H6.6740.000
299127TYRHE2H6.6740.000
300127TYRCAC57.4030.000
301127TYRCBC39.0490.000
302127TYRNN125.2430.000
303128CYSHH9.0500.000
304128CYSHAH5.0490.000
305128CYSHB2H3.1650.004
306128CYSHB3H2.9830.000
307128CYSCAC54.6550.000
308128CYSCBC43.4390.000
309128CYSNN128.0830.000
310129CYSHH9.0120.000
311129CYSHAH5.3400.000
312129CYSHB2H3.0930.004
313129CYSHB3H2.5190.000
314129CYSCAC51.7830.000
315129CYSCBC44.5520.023
316129CYSNN120.6910.000
317130PROHAH4.6450.000
318130PROHB2H2.4750.002
319130PROHB3H2.0310.006
320130PROHG2H2.2520.004
321130PROHG3H2.1610.003
322130PROHD2H3.9950.004
323130PROHD3H3.6890.004
324130PROCAC63.3480.000
325130PROCBC32.3870.000
326130PROCGC27.8800.000
327130PROCDC51.2360.000
328131ARGHH8.4340.000
329131ARGHAH4.1120.000
330131ARGHB2H1.7920.002
331131ARGHB3H1.6870.000
332131ARGHG2H1.5640.002
333131ARGHG3H1.5640.002
334131ARGHD2H3.1520.001
335131ARGHD3H3.1520.001
336131ARGHEH7.2170.001
337131ARGCAC57.0160.000
338131ARGCBC30.7470.000
339131ARGCGC27.6660.000
340131ARGCDC43.2520.000
341131ARGNN121.8560.000
342132ARGHH7.8810.000
343132ARGHAH4.1510.000
344132ARGHB2H1.8330.002
345132ARGHB3H1.7100.002
346132ARGHG2H1.5650.002
347132ARGHG3H1.5650.002
348132ARGHD2H3.1970.001
349132ARGHD3H3.1970.001
350132ARGHEH7.2170.000
351132ARGCAC57.1640.000
352132ARGCBC31.6580.000
353132ARGCGC27.5680.000
354132ARGCDC43.2630.000

Release date
2021-08-03
Citation
A conserved beta-bulge glycine residue facilitates folding and increases stability of the mouse alpha-defensin cryptdin-4
Clark, R.J., Phan, T.H., Song, A., Ouellette, A.J., Conibear, A.C., Rosengren, K.J.
Pept. Sci. (2022), 114, e24250-e24250, PubMed , DOI 10.1002/pep2.24250
Related entities 1. Alpha-defensin 4, : 1 : 7 : 23 entities Detail
Experiments performed 6 experiments Detail
Chemical shift validation 3 contents Detail
Keywords ANTIMICROBIAL PROTEIN, Cryptdin