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BMRB: 31150

Chemical shifts of CD28 hinge (I114-P152) used in chimeric antigen receptor (CAR) T-cells
Authors
Folimonova, V., Chen, X., Schwieters, C.D., Walters, K.J.
Assembly
T-cell-specific surface glycoprotein CD28
Entity
1. T-cell-specific surface glycoprotein CD28 (polymer), 44 monomers, 4713.431 Da Detail

GPLGSIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKP


Formula weight
4713.431 Da
Source organism
Homo sapiens
Exptl. method
solution NMR
Data set
assigned_chemical_shifts
Chemcal Shifts
1H: 280, 13C: 179, 15N: 33 assignments Detail
Download
IDEntity IDSeq IDComp IDAtom IDAtom typeValVal errAmbig. code
116ILEHH8.2610.0001
216ILEHAH4.1760.0001
316ILEHBH1.8500.0001
416ILEHG12H1.4260.0001
516ILEHG13H1.1630.0001
616ILEHG21H0.8690.0001
716ILEHG22H0.8690.0001
816ILEHG23H0.8690.0001
916ILEHD11H0.8320.0001
1016ILEHD12H0.8320.0001
1116ILEHD13H0.8320.0001
1216ILECC176.1550.0001
1316ILECAC60.8190.0001
1416ILECBC38.8260.0001
1516ILECG1C26.8140.0001
1616ILECG2C17.3040.0001
1716ILECD1C12.8780.0001
1816ILENN122.4440.0001
1917GLUHH8.4700.0001
2017GLUHAH4.2330.0001
2117GLUHB2H1.9520.0002
2217GLUHB3H1.8670.0002
2317GLUHG2H2.2230.0002
2417GLUHG3H2.1670.0002
2517GLUCC176.1080.0001
2617GLUCAC56.3460.0001
2717GLUCBC30.1310.0001
2817GLUCGC36.1680.0001
2917GLUNN125.2510.0001
3018VALHH8.1930.0001
3118VALHAH3.9390.0001
3218VALHBH1.9150.0001
3318VALHG11H0.8500.0002
3418VALHG12H0.8500.0002
3518VALHG13H0.8500.0002
3618VALHG21H0.7020.0002
3718VALHG22H0.7020.0002
3818VALHG23H0.7020.0002
3918VALCC175.5160.0001
4018VALCAC62.1740.0001
4118VALCBC32.3560.0001
4218VALCG1C20.3070.0002
4318VALCG2C20.8080.0002
4418VALNN122.4390.0001
4519METHH8.2990.0001
4619METHAH4.3670.0001
4719METHB2H1.8320.0002
4819METHB3H1.8320.0002
4919METHG2H2.4280.0002
5019METHG3H2.3160.0002
5119METHE1H2.0020.0001
5219METHE2H2.0020.0001
5319METHE3H2.0020.0001
5419METCC175.3140.0001
5519METCAC55.0270.0001
5619METCBC32.8200.0001
5719METCGC31.7580.0001
5819METCEC16.8220.0001
5919METNN124.3330.0001
60110TYRHH8.2510.0001
61110TYRHAH4.8150.0001
62110TYRHB2H3.0280.0002
63110TYRHB3H2.7440.0002
64110TYRHD1H7.1200.0003
65110TYRHD2H7.1200.0003
66110TYRHE1H6.7650.0003
67110TYRHE2H6.7650.0003
68110TYRCC173.1710.0001
69110TYRCAC55.2810.0001
70110TYRCBC38.0530.0001
71110TYRCD1C133.1920.0003
72110TYRCD2C133.1920.0003
73110TYRCE1C118.1250.0003
74110TYRCE2C118.1250.0003
75110TYRNN122.0890.0001
76111PROHAH4.6600.0001
77111PROHB2H2.2880.0002
78111PROHB3H1.8770.0002
79111PROHG2H1.9920.0002
80111PROHG3H1.9920.0002
81111PROHD2H3.7360.0002
82111PROHD3H3.5990.0002
83111PROCC174.1250.0001
84111PROCAC61.2830.0001
85111PROCBC30.5130.0001
86111PROCGC27.1730.0001
87111PROCDC50.3440.0001
88112PROHAH4.6670.0001
89112PROHB2H2.2960.0002
90112PROHB3H1.8000.0002
91112PROHG2H1.9840.0002
92112PROHG3H1.9840.0002
93112PROHD2H3.8100.0002
94112PROHD3H3.5920.0002
95112PROCC174.9550.0001
96112PROCAC61.4350.0001
97112PROCBC30.8700.0001
98112PROCGC27.1390.0001
99112PROCDC50.3400.0001
100113PROHAH4.3500.0001
101113PROHB2H2.1960.0002
102113PROHB3H1.7720.0002
103113PROHG2H1.9680.0002
104113PROHG3H1.9450.0002
105113PROHD2H3.7780.0002
106113PROHD3H3.6710.0002
107113PROCC176.4910.0001
108113PROCAC62.8520.0001
109113PROCBC31.8550.0001
110113PROCGC26.9260.0001
111113PROCDC50.3620.0001
112114TYRHH8.0820.0001
113114TYRHAH4.5090.0001
114114TYRHB2H2.9680.0002
115114TYRHB3H2.9680.0002
116114TYRHD1H7.0720.0003
117114TYRHD2H7.0720.0003
118114TYRHE1H6.7860.0003
119114TYRHE2H6.7860.0003
120114TYRCC175.4750.0001
121114TYRCAC57.4700.0001
122114TYRCBC38.4720.0001
123114TYRCD1C133.1920.0003
124114TYRCD2C133.1920.0003
125114TYRCE1C118.0120.0003
126114TYRCE2C118.0120.0003
127114TYRNN119.7340.0001
128115LEUHH8.0840.0001
129115LEUHAH4.2830.0001
130115LEUHB2H1.4750.0002
131115LEUHB3H1.4750.0002
132115LEUHGH1.4210.0001
133115LEUHD11H0.8480.0002
134115LEUHD12H0.8480.0002
135115LEUHD13H0.8480.0002
136115LEUHD21H0.7930.0002
137115LEUHD22H0.7930.0002
138115LEUHD23H0.7930.0002
139115LEUCC176.4090.0001
140115LEUCAC54.3440.0001
141115LEUCBC42.6430.0001
142115LEUCGC26.8140.0001
143115LEUCD1C24.8150.0002
144115LEUCD2C23.3100.0002
145115LEUNN124.9650.0001
146116ASPHH8.2060.0001
147116ASPHAH4.4820.0001
148116ASPHB2H2.6850.0002
149116ASPHB3H2.5440.0002
150116ASPCC176.1220.0001
151116ASPCAC54.0880.0001
152116ASPCBC40.9750.0001
153116ASPNN121.5470.0001
154117ASNHH8.3890.0001
155117ASNHAH4.6290.0001
156117ASNHB2H2.7690.0002
157117ASNHB3H2.7330.0002
158117ASNHD21H7.6380.0002
159117ASNHD22H6.8990.0002
160117ASNCC175.5690.0001
161117ASNCAC53.3010.0001
162117ASNCBC38.6590.0001
163117ASNNN119.1570.0001
164117ASNND2N113.0050.0001
165118GLUHH8.4130.0001
166118GLUHAH4.2140.0001
167118GLUHB2H2.0380.0002
168118GLUHB3H1.9540.0002
169118GLUHG2H2.2590.0002
170118GLUHG3H2.1910.0002
171118GLUCC176.8720.0001
172118GLUCAC56.6700.0001
173118GLUCBC29.9330.0001
174118GLUCGC36.2220.0001
175118GLUNN120.6660.0001
176119LYSHH8.2350.0001
177119LYSHAH4.3690.0001
178119LYSHB2H1.8320.0002
179119LYSHB3H1.7340.0002
180119LYSHG2H1.4060.0002
181119LYSHG3H1.3700.0002
182119LYSHD2H1.6300.0002
183119LYSHD3H1.6300.0002
184119LYSHE2H2.9450.0002
185119LYSHE3H2.9450.0002
186119LYSCC176.9310.0001
187119LYSCAC55.8460.0001
188119LYSCBC33.0880.0001
189119LYSCGC24.5370.0001
190119LYSCDC28.8160.0001
191119LYSCEC41.6880.0001
192119LYSNN121.2080.0001
193120SERHH8.2890.0001
194120SERHAH4.4240.0001
195120SERHB2H3.8400.0002
196120SERHB3H3.7990.0002
197120SERCC174.6300.0001
198120SERCAC58.2550.0001
199120SERCBC63.4060.0001
200120SERNN116.1740.0001
201121ASNHH8.4790.0001
202121ASNHAH4.7030.0001
203121ASNHB2H2.8050.0002
204121ASNHB3H2.8050.0002
205121ASNHD21H7.6610.0002
206121ASNHD22H6.9470.0002
207121ASNCC175.8040.0001
208121ASNCAC53.2150.0001
209121ASNCBC38.5740.0001
210121ASNNN120.8760.0001
211121ASNND2N113.0630.0001
212122GLYHH8.3960.0001
213122GLYHA2H3.9730.0002
214122GLYHA3H3.9080.0002
215122GLYCC174.2240.0001
216122GLYCAC45.0280.0001
217122GLYNN108.9820.0001
218123THRHH8.0730.0001
219123THRHAH4.2760.0001
220123THRHBH4.1370.0001
221123THRHG21H1.1550.0001
222123THRHG22H1.1550.0001
223123THRHG23H1.1550.0001
224123THRCC174.3060.0001
225123THRCAC62.4130.0001
226123THRCBC69.5690.0001
227123THRCG2C21.5040.0001
228123THRNN114.5480.0001
229124ILEHH8.2110.0001
230124ILEHAH4.0790.0001
231124ILEHBH1.7570.0001
232124ILEHG12H1.4070.0001
233124ILEHG13H1.0900.0001
234124ILEHG21H0.6870.0001
235124ILEHG22H0.6870.0001
236124ILEHG23H0.6870.0001
237124ILEHD11H0.7790.0001
238124ILEHD12H0.7790.0001
239124ILEHD13H0.7790.0001
240124ILECC175.7380.0001
241124ILECAC60.7040.0001
242124ILECBC38.3250.0001
243124ILECG1C27.0980.0001
244124ILECG2C17.0610.0001
245124ILECD1C12.4920.0001
246124ILENN124.3140.0001
247125ILEHH8.2610.0001
248125ILEHAH4.0750.0001
249125ILEHBH1.7390.0001
250125ILEHG12H1.3640.0001
251125ILEHG13H1.0880.0001
252125ILEHG21H0.7770.0001
253125ILEHG22H0.7770.0001
254125ILEHG23H0.7770.0001
255125ILEHD11H0.7690.0001
256125ILEHD12H0.7690.0001
257125ILEHD13H0.7690.0001
258125ILECC175.7560.0001
259125ILECAC60.5600.0001
260125ILECBC38.2540.0001
261125ILECG1C26.9060.0001
262125ILECG2C17.0680.0001
263125ILECD1C12.4030.0001
264125ILENN125.8760.0001
265126HISHH8.5390.0001
266126HISHAH4.6050.0001
267126HISHB2H2.9960.0002
268126HISHB3H2.9400.0002
269126HISHD2H6.9040.0001
270126HISCC174.8490.0001
271126HISCAC56.0120.0001
272126HISCBC31.0780.0001
273126HISCD2C119.2490.0001
274126HISNN124.9440.0001
275127VALHH8.3160.0001
276127VALHAH4.0220.0001
277127VALHBH1.9850.0001
278127VALHG11H0.8870.0002
279127VALHG12H0.8870.0002
280127VALHG13H0.8870.0002
281127VALHG21H0.8570.0002
282127VALHG22H0.8570.0002
283127VALHG23H0.8570.0002
284127VALCC175.9020.0001
285127VALCAC62.0550.0001
286127VALCBC32.6230.0001
287127VALCG1C20.5180.0002
288127VALCG2C20.2720.0802
289127VALNN123.2200.0001
290128LYSHH8.5630.0001
291128LYSHAH4.2390.0001
292128LYSHB2H1.8040.0002
293128LYSHB3H1.7260.0002
294128LYSHG2H1.4500.0002
295128LYSHG3H1.3900.0002
296128LYSHD2H1.6430.0002
297128LYSHD3H1.6430.0002
298128LYSHE2H2.9450.0002
299128LYSHE3H2.9450.0002
300128LYSCC176.9780.0001
301128LYSCAC56.5420.0001
302128LYSCBC32.5450.0001
303128LYSCGC24.6190.0001
304128LYSCDC28.8160.0001
305128LYSCEC41.9610.0001
306128LYSNN125.8760.0001
307129GLYHH8.5230.0001
308129GLYHA2H4.0080.0002
309129GLYHA3H3.8500.0002
310129GLYCC173.8660.0001
311129GLYCAC45.3350.0001
312129GLYNN110.6360.0001
313130LYSHH8.2240.0001
314130LYSHAH4.2280.0001
315130LYSHB2H1.7180.0002
316130LYSHB3H1.6620.0002
317130LYSHG2H1.3240.0002
318130LYSHG3H1.2880.0002
319130LYSHD2H1.6110.0002
320130LYSHD3H1.6110.0002
321130LYSHE2H2.9120.0002
322130LYSHE3H2.9120.0002
323130LYSCC176.3050.0001
324130LYSCAC56.2170.0001
325130LYSCBC32.7930.0001
326130LYSCGC24.4850.0001
327130LYSCDC28.8160.0001
328130LYSCEC41.7140.0001
329130LYSNN120.8760.0001
330131HISHH8.5020.0001
331131HISHAH4.5500.0001
332131HISHB2H3.0230.0002
333131HISHB3H2.9920.0002
334131HISHD2H6.9040.0001
335131HISCC174.7660.0001
336131HISCAC56.1810.0001
337131HISCBC30.8350.0001
338131HISCD2C119.3360.0001
339131HISNN120.5630.0001
340132LEUHH8.3030.0001
341132LEUHAH4.2870.0001
342132LEUHB2H1.5570.0002
343132LEUHB3H1.4760.0002
344132LEUHGH1.3580.0001
345132LEUHD11H0.8440.0002
346132LEUHD12H0.8440.0002
347132LEUHD13H0.8440.0002
348132LEUHD21H0.7710.0002
349132LEUHD22H0.7710.0002
350132LEUHD23H0.7710.0002
351132LEUCC176.7620.0001
352132LEUCAC54.5450.0001
353132LEUCBC41.9610.0001
354132LEUCGC26.7030.0001
355132LEUCD1C24.8120.0002
356132LEUCD2C23.4760.0002
357132LEUNN124.2340.0001
358133CYSHH8.4470.0001
359133CYSHAH4.6750.0001
360133CYSHB2H2.8650.0002
361133CYSHB3H2.7860.0002
362133CYSCC172.5030.0001
363133CYSCAC56.4890.0001
364133CYSCBC27.3140.0001
365133CYSNN122.0470.0001
366134PROHAH4.4130.0001
367134PROHB2H2.2390.0002
368134PROHB3H1.8870.0002
369134PROHG2H1.9710.0002
370134PROHG3H1.9710.0002
371134PROHD2H3.7330.0002
372134PROHD3H3.7330.0002
373134PROCC176.5270.0001
374134PROCAC63.0480.0001
375134PROCBC32.1020.0001
376134PROCGC27.0480.0001
377134PROCDC50.5730.0001
378135SERHH8.4510.0001
379135SERHAH4.7100.0001
380135SERHB2H3.8150.0002
381135SERHB3H3.8150.0002
382135SERCC172.9070.0001
383135SERCAC56.2110.0001
384135SERCBC63.1580.0001
385135SERNN117.6730.0001
386136PROHAH4.2710.0001
387136PROHB2H2.1590.0002
388136PROHB3H1.7570.0002
389136PROHG2H1.9600.0002
390136PROHG3H1.9160.0002
391136PROHD2H3.6710.0002
392136PROHD3H3.5970.0002
393136PROCC176.5440.0001
394136PROCAC62.7670.0001
395136PROCBC31.7180.0001
396136PROCGC27.1670.0001
397136PROCDC50.3550.0001
398137LEUHH8.1780.0001
399137LEUHAH4.1600.0001
400137LEUHB2H1.4710.0002
401137LEUHB3H1.3230.0002
402137LEUHGH1.4680.0001
403137LEUHD11H0.8480.0002
404137LEUHD12H0.8480.0002
405137LEUHD13H0.8480.0002
406137LEUHD21H0.7770.0002
407137LEUHD22H0.7770.0002
408137LEUHD23H0.7770.0002
409137LEUCC176.6530.0001
410137LEUCAC55.0270.0001
411137LEUCBC42.1930.0001
412137LEUCGC26.8140.0001
413137LEUCD1C24.6280.0002
414137LEUCD2C23.1870.0002
415137LEUNN121.3450.0001
416138PHEHH8.1180.0001
417138PHEHAH4.8950.0001
418138PHEHB2H3.1110.0002
419138PHEHB3H2.9130.0002
420138PHEHD1H7.2560.0003
421138PHEHD2H7.2560.0003
422138PHECC173.8110.0001
423138PHECAC55.0500.0001
424138PHECBC39.0950.0001
425138PHECD1C132.1930.0001
426138PHECD2C132.1930.0001
427138PHENN120.8760.0001
428139PROHAH4.4190.0001
429139PROHB2H2.2880.0002
430139PROHB3H2.2160.0002
431139PROHG2H1.9740.0002
432139PROHG3H1.9490.0002
433139PROHD2H3.6790.0002
434139PROHD3H3.5350.0002
435139PROCC177.0600.0001
436139PROCAC62.9140.0001
437139PROCBC32.3490.0001
438139PROCGC27.1730.0001
439139PROCDC50.5900.0001
440140GLYHH8.0360.0001
441140GLYHA2H4.1100.0002
442140GLYHA3H3.9940.0002
443140GLYCC171.5270.0001
444140GLYCAC44.1830.0001
445140GLYNN108.9610.0001
446141PROHAH4.4560.0001
447141PROHB2H2.2740.0002
448141PROHB3H1.9270.0002
449141PROHG2H1.9980.0002
450141PROHG3H1.9980.0002
451141PROHD2H3.6150.0002
452141PROHD3H3.6150.0002
453141PROCC177.1700.0001
454141PROCAC63.0320.0001
455141PROCBC32.1320.0001
456141PROCGC27.0350.0001
457141PROCDC49.5480.0001
458142SERHH8.5090.0001
459142SERHAH4.3830.0001
460142SERHB2H3.8110.0002
461142SERHB3H3.8110.0002
462142SERCC174.0030.0001
463142SERCAC58.2090.0001
464142SERCBC63.5450.0001
465142SERNN116.9320.0001
466143LYSHH8.3570.0001
467143LYSHAH4.6010.0001
468143LYSHB2H1.8260.0002
469143LYSHB3H1.6970.0002
470143LYSHG2H1.4370.0002
471143LYSHG3H1.4370.0002
472143LYSHD2H1.6440.0002
473143LYSHD3H1.6440.0002
474143LYSHE2H2.9470.0002
475143LYSHE3H2.9470.0002
476143LYSCC173.5770.0001
477143LYSCAC53.8440.0001
478143LYSCBC32.3190.0001
479143LYSCGC24.4620.0001
480143LYSCDC28.6320.0001
481143LYSNN124.7820.0001
482144PROHAH4.1930.0001
483144PROHB2H2.1840.0002
484144PROHB3H1.8540.0002
485144PROHG2H1.9100.0002
486144PROHG3H1.9100.0002
487144PROHD2H3.6150.0002
488144PROHD3H3.7400.0002
489144PROCAC64.6390.0001
490144PROCBC31.6090.0001
491144PROCGC26.9260.0001
492144PROCDC50.0970.0001

Release date
2024-03-05
Citation
CD28 hinge used in chimeric antigen receptor (CAR) T-cells exhibits local structure and conformational exchange amidst global disorder
Folimonova, V., Chen, X., Negi, H., Schwieters, C.D., Li, J., Byrd, R.A., Taylor, N., Youkharibache, P., Walters, K.J.
Commun. Biol. (2024), 7, 1072-1072, PubMed 39217198 , DOI 10.1038/s42003-024-06770-w ,
Experiments performed 29 experiments Detail
Chemical shift validation 3 contents Detail
Keywords CAR-T, CD28, IMMUNE SYSTEM, immunotherapy, intrinsic disorder