BMRB: 34266

exendin-4 based dual GLP-1/glucagon receptor agonist

Authors

Evers, A., Kurz, M.

Assembly

Exendin-4

Entity

1. Exendin-4, entity 1 (polymer, Thiol state: not present), 40 monomers, 4273.823 Da Detail

HXQGTFTSDL SKQKDEQRAK LFIEWLXAGG PPSXKPPPKX

2. Exendin-4, entity EVT (non-polymer), 514.652 Da

Total weight

4788.475 Da

Max. entity weight

4273.823 Da

Source organism

Heloderma suspectum

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 87.5 %, Completeness: 95.3 %, Completeness (bb): 94.3 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	95.3 % (224 of 235)	95.3 % (224 of 235)
Backbone	94.3 % (66 of 70)	94.3 % (66 of 70)
Sidechain	95.8 % (158 of 165)	95.8 % (158 of 165)
Aromatic	100.0 % (18 of 18)	100.0 % (18 of 18)
Methyl	100.0 % (12 of 12)	100.0 % (12 of 12)

1. entity 1

HXQGTFTSDL SKQKDEQRAK LFIEWLXAGG PPSXKPPPKX

Show sample condition

Sample

Solvent system trifluoroethanol/water, Pressure 1 (±0.01) Pa, Temperature 310 (±0.2) K, pH 5.0 (±0.05), Details 5 mg/mL Peptide 12, trifluoroethanol/water

#	Name	Isotope labeling	Type	Concentration
1	Peptide 12	natural abundance		5 mg/mL
2	sodium phosphate	natural abundance		35 mM

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Release date

2018-06-17

Citation

Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations
Evers, A., Bossart, M., Pfeiffer-Marek, S., Elvert, R., Schreuder, H.A., Kurz, M., Stengelin, S., Lorenz, M., Herling, A., Konkar, A.A., Lukasczyk, U., Pfenninger, A., Lorenz, K., Haack, T., Kadereit, D., Wagner, M.
J. Med. Chem. (2018), 61, 5580-5593, PubMed 29879354 , DOI 10.1021/acs.jmedchem.8b00292 , Abstract

Entries sharing articles BMRB: 1 entries Detail

Related entities 1. Exendin-4, entity 1, : 1 : 20 entities Detail

Experiments performed 4 experiments Detail