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Structure of Insulin receptor-related receptor's transmembrane domain
Authors
Bershatsky, Y.V., Nadezhdin, K.D., Bocharova, O.V., Bocharov, E.V.
Assembly
Insulin-like growth factor 1 receptor (E.C.2.7.10.1)
Entity
1. Insulin-like growth factor 1 receptor (E.C.2.7.10.1) (polymer, Thiol state: not present), 31 monomers, 3239.934 Da Detail

GGLHVLLTAT PVGLTLLIVL AALGFFYGKK R


Formula weight
3239.934 Da
Source organism
Homo sapiens
Exptl. method
solution NMR
Data set
assigned_chemical_shifts
Chemcal Shifts
1H: 230, 13C: 135, 15N: 30 assignments Detail
IDEntity IDSeq IDComp IDAtom IDAtom typeValVal errAmbig. code
111GLYHA2H3.9890.0201
211GLYHA3H3.9890.0201
311GLYCAC45.9600.31
411GLYNN107.0280.31
512GLYHH8.3930.0201
612GLYHA2H4.0330.0201
712GLYHA3H4.0330.0201
812GLYCAC45.9320.31
912GLYNN108.2940.31
1013LEUHH8.6550.0201
1113LEUHAH4.1460.0201
1213LEUHB2H1.7370.0202
1313LEUHB3H1.6750.0202
1413LEUHGH1.8280.0201
1513LEUHD11H0.9780.0202
1613LEUHD12H0.9780.0202
1713LEUHD13H0.9780.0202
1813LEUHD21H0.9600.0202
1913LEUHD22H0.9600.0202
2013LEUHD23H0.9600.0202
2113LEUCC177.8870.31
2213LEUCAC57.5640.31
2313LEUCBC42.2620.31
2413LEUCGC27.0470.31
2513LEUCD1C24.6530.31
2613LEUCD2C24.4370.31
2713LEUNN121.4920.31
2814HISHH8.4370.0201
2914HISHAH4.2260.0201
3014HISHB2H3.2770.0202
3114HISHB3H3.2250.0202
3214HISHD2H7.0320.0201
3314HISCAC59.8370.31
3414HISCBC30.3700.31
3514HISCD2C119.1950.31
3614HISNN116.9250.31
3715VALHH7.5340.0201
3815VALHAH3.8160.0201
3915VALHBH2.1720.0201
4015VALHG11H1.0010.0202
4115VALHG12H1.0010.0202
4215VALHG13H1.0010.0202
4315VALHG21H0.9640.0202
4415VALHG22H0.9640.0202
4515VALHG23H0.9640.0202
4615VALCC177.4040.31
4715VALCAC65.1290.31
4815VALCBC31.8000.31
4915VALCG1C21.8010.31
5015VALCG2C21.1890.31
5115VALNN118.8360.31
5216LEUHH7.8820.0201
5316LEUHAH4.1730.0201
5416LEUHB2H1.8930.0202
5516LEUHB3H1.6870.0202
5616LEUHGH1.8360.0201
5716LEUHD11H1.0220.0202
5816LEUHD12H1.0220.0202
5916LEUHD13H1.0220.0202
6016LEUHD21H0.9270.0202
6116LEUHD22H0.9270.0202
6216LEUHD23H0.9270.0202
6316LEUCC178.1400.31
6416LEUCAC57.4380.31
6516LEUCBC42.1870.31
6616LEUCGC27.2130.31
6716LEUCD1C25.0380.31
6816LEUCD2C24.7510.31
6916LEUNN119.8190.31
7017LEUHH7.8990.0201
7117LEUHAH4.2320.0201
7217LEUHB2H1.9210.0202
7317LEUHB3H1.7860.0202
7417LEUHGH1.8510.0201
7517LEUHD11H0.9670.0202
7617LEUHD12H0.9670.0202
7717LEUHD13H0.9670.0202
7817LEUHD21H0.8980.0202
7917LEUHD22H0.8980.0202
8017LEUHD23H0.8980.0202
8117LEUCC177.0480.31
8217LEUCAC56.5890.31
8317LEUCBC41.8750.31
8417LEUCGC27.1450.31
8517LEUCD1C25.7210.31
8617LEUCD2C23.3930.31
8717LEUNN115.4390.31
8818THRHH7.5680.0201
8918THRHAH4.4180.0201
9018THRHBH4.4370.0201
9118THRHG21H1.2530.0201
9218THRHG22H1.2530.0201
9318THRHG23H1.2530.0201
9418THRCAC62.6570.31
9518THRCBC69.9210.31
9618THRCG2C22.0000.31
9718THRNN106.6010.31
9819ALAHH8.0670.0201
9919ALAHAH4.4920.0201
10019ALAHB1H1.5620.0201
10119ALAHB2H1.5620.0201
10219ALAHB3H1.5620.0201
10319ALACC177.5790.31
10419ALACAC53.0710.31
10519ALACBC19.7430.31
10619ALANN122.6250.31
107110THRHH7.9500.0201
108110THRHAH4.4880.0201
109110THRHBH4.5410.0201
110110THRHG21H1.3590.0201
111110THRHG22H1.3590.0201
112110THRHG23H1.3590.0201
113110THRCAC62.2100.31
114110THRCBC68.8240.31
115110THRCG2C21.8410.31
116110THRNN111.4800.31
117111PROHAH4.4230.0201
118111PROHB2H2.3820.0202
119111PROHB3H2.0220.0202
120111PROHG2H2.0880.0202
121111PROHG3H2.2420.0202
122111PROHD2H3.9280.0202
123111PROHD3H3.9030.0202
124111PROCAC65.0200.31
125111PROCBC31.9670.31
126111PROCGC28.1310.31
127111PROCDC50.6910.31
128112VALHH8.1440.0201
129112VALHAH3.6890.0201
130112VALHBH2.2030.0201
131112VALHG11H1.1210.0202
132112VALHG12H1.1210.0202
133112VALHG13H1.1210.0202
134112VALHG21H0.9420.0202
135112VALHG22H0.9420.0202
136112VALHG23H0.9420.0202
137112VALCC175.0140.31
138112VALCAC66.7660.31
139112VALCBC31.5730.31
140112VALCG1C23.1930.31
141112VALCG2C21.2850.31
142112VALNN119.1420.31
143113GLYHH8.2300.0201
144113GLYHA2H3.9440.0202
145113GLYHA3H3.7360.0202
146113GLYCAC47.8700.31
147113GLYNN107.1650.31
148114LEUHH8.2170.0201
149114LEUHAH4.1350.0201
150114LEUHB2H1.7190.0202
151114LEUHB3H1.6790.0202
152114LEUHGH1.7960.0201
153114LEUHD11H0.9370.0202
154114LEUHD12H0.9370.0202
155114LEUHD13H0.9370.0202
156114LEUHD21H0.9300.0202
157114LEUHD22H0.9300.0202
158114LEUHD23H0.9300.0202
159114LEUCC177.9030.31
160114LEUCAC57.9480.31
161114LEUCBC42.1510.31
162114LEUCGC27.2350.31
163114LEUCD1C24.6340.31
164114LEUCD2C24.1320.31
165114LEUNN119.2160.31
166115THRHH7.7990.0201
167115THRHAH4.2920.0201
168115THRHBH3.7370.0201
169115THRHG21H1.1540.0201
170115THRHG22H1.1540.0201
171115THRHG23H1.1540.0201
172115THRCAC66.6850.31
173115THRCBC67.9250.31
174115THRCG2C21.5660.31
175115THRNN114.4570.31
176116LEUHH8.0960.0201
177116LEUHAH3.9640.0201
178116LEUHB2H1.8630.0202
179116LEUHB3H1.7060.0202
180116LEUHGH1.8760.0201
181116LEUHD11H0.8760.0202
182116LEUHD12H0.8760.0202
183116LEUHD13H0.8760.0202
184116LEUHD21H1.0810.0202
185116LEUHD22H1.0810.0202
186116LEUHD23H1.0810.0202
187116LEUCC177.8950.31
188116LEUCAC58.3310.31
189116LEUCBC41.7030.31
190116LEUCGC26.9130.31
191116LEUCD1C24.2350.31
192116LEUCD2C23.1210.31
193116LEUNN119.5870.31
194117LEUHH7.9500.0201
195117LEUHAH4.0220.0201
196117LEUHB2H1.8630.0202
197117LEUHB3H1.6960.0202
198117LEUHGH1.8110.0201
199117LEUHD11H0.9960.0202
200117LEUHD12H0.9960.0202
201117LEUHD13H0.9960.0202
202117LEUHD21H0.8670.0202
203117LEUHD22H0.8670.0202
204117LEUHD23H0.8670.0202
205117LEUCC177.9570.31
206117LEUCAC58.6600.31
207117LEUCBC42.1710.31
208117LEUCGC26.9350.31
209117LEUCD1C25.3760.31
210117LEUCD2C24.0840.31
211117LEUNN117.8110.31
212118ILEHH8.0200.0201
213118ILEHAH3.6690.0201
214118ILEHBH2.1140.0201
215118ILEHG12H1.8950.0202
216118ILEHG13H1.1390.0202
217118ILEHG21H0.9190.0201
218118ILEHG22H0.9190.0201
219118ILEHG23H0.9190.0201
220118ILEHD11H0.8430.0201
221118ILEHD12H0.8430.0201
222118ILEHD13H0.8430.0201
223118ILECC177.4280.31
224118ILECAC65.4250.31
225118ILECBC37.4320.31
226118ILECG1C29.5120.31
227118ILECG2C17.2210.31
228118ILECD1C13.0290.31
229118ILENN117.6680.31
230119VALHH8.2470.0201
231119VALHAH3.6110.0201
232119VALHBH2.2940.0201
233119VALHG11H1.0040.0202
234119VALHG12H1.0040.0202
235119VALHG13H1.0040.0202
236119VALHG21H0.9700.0202
237119VALHG22H0.9700.0202
238119VALHG23H0.9700.0202
239119VALCC177.6970.31
240119VALCAC67.4840.31
241119VALCBC31.4560.31
242119VALCG1C21.4390.31
243119VALCG2C21.4350.31
244119VALNN118.9830.31
245120LEUHH8.5390.0201
246120LEUHAH4.0800.0201
247120LEUHB2H2.0200.0202
248120LEUHB3H1.4940.0202
249120LEUHGH1.9770.0201
250120LEUHD11H0.8650.0202
251120LEUHD12H0.8650.0202
252120LEUHD13H0.8650.0202
253120LEUHD21H0.8590.0202
254120LEUHD22H0.8590.0202
255120LEUHD23H0.8590.0202
256120LEUCC178.7580.31
257120LEUCAC58.4820.31
258120LEUCBC41.6630.31
259120LEUCGC26.9090.31
260120LEUCD1C25.2370.31
261120LEUCD2C23.1300.31
262120LEUNN118.3820.31
263121ALAHH8.5930.0201
264121ALAHAH4.0660.0201
265121ALAHB1H1.5230.0201
266121ALAHB2H1.5230.0201
267121ALAHB3H1.5230.0201
268121ALACC179.0660.31
269121ALACAC55.4260.31
270121ALACBC18.0070.31
271121ALANN120.5070.31
272122ALAHH8.6470.0201
273122ALAHAH4.1500.0201
274122ALAHB1H1.6450.0201
275122ALAHB2H1.6450.0201
276122ALAHB3H1.6450.0201
277122ALACC179.7710.31
278122ALACAC55.7710.31
279122ALACBC18.2280.31
280122ALANN119.6940.31
281123LEUHH8.7000.0201
282123LEUHAH4.2900.0201
283123LEUHB2H2.1400.0202
284123LEUHB3H1.6270.0202
285123LEUHGH2.0990.0201
286123LEUHD11H0.9540.0202
287123LEUHD12H0.9540.0202
288123LEUHD13H0.9540.0202
289123LEUHD21H0.9900.0202
290123LEUHD22H0.9900.0202
291123LEUHD23H0.9900.0202
292123LEUCC179.5970.31
293123LEUCAC58.5890.31
294123LEUCBC42.1630.31
295123LEUCGC26.9840.31
296123LEUCD1C25.6170.31
297123LEUCD2C23.8540.31
298123LEUNN117.7130.31
299124GLYHH8.9820.0201
300124GLYHA2H3.7120.0202
301124GLYHA3H3.8190.0202
302124GLYCC175.1330.31
303124GLYCAC47.8260.31
304124GLYNN106.7840.31
305125PHEHH8.7950.0201
306125PHEHAH4.2290.0201
307125PHEHB2H3.1430.0202
308125PHEHB3H3.1840.0202
309125PHEHD1H7.3410.0201
310125PHEHD2H7.3410.0201
311125PHEHE1H7.3770.0201
312125PHEHE2H7.3770.0201
313125PHEHZH7.3240.0201
314125PHECC177.1990.31
315125PHECAC61.8060.31
316125PHECBC39.8260.31
317125PHECD1C131.9820.31
318125PHECD2C131.9820.31
319125PHECE1C131.0810.31
320125PHECE2C131.0810.31
321125PHECZC129.5660.31
322125PHENN121.3740.31
323126PHEHH8.6560.0201
324126PHEHAH4.2040.0201
325126PHEHB2H3.2100.0202
326126PHEHB3H3.1480.0202
327126PHEHD1H7.1720.0201
328126PHEHD2H7.1720.0201
329126PHEHE1H7.2030.0201
330126PHEHE2H7.2030.0201
331126PHEHZH7.2860.0201
332126PHECC177.5470.31
333126PHECAC61.7910.31
334126PHECBC39.6750.31
335126PHECD1C132.7500.31
336126PHECD2C132.7500.31
337126PHECE1C131.0320.31
338126PHECE2C131.0320.31
339126PHECZC129.5940.31
340126PHENN116.6140.31
341127TYRHH8.7740.0201
342127TYRHAH4.3330.0201
343127TYRHB2H3.2090.0202
344127TYRHB3H3.1460.0202
345127TYRHD1H6.8920.0201
346127TYRHD2H6.8920.0201
347127TYRHE1H6.8630.0201
348127TYRHE2H6.8630.0201
349127TYRCC177.1910.31
350127TYRCAC61.0050.31
351127TYRCBC39.2540.31
352127TYRCD1C131.6760.31
353127TYRCD2C131.6760.31
354127TYRCE1C118.1270.31
355127TYRCE2C118.1270.31
356127TYRNN117.4860.31
357128GLYHH8.3010.0201
358128GLYHA2H3.8060.0202
359128GLYHA3H3.9090.0202
360128GLYCC174.0640.31
361128GLYCAC46.4040.31
362128GLYNN106.2650.31
363129LYSHH7.6530.0201
364129LYSHAH4.2900.0201
365129LYSHB2H1.7570.0202
366129LYSHB3H1.8820.0202
367129LYSHG2H1.3550.0201
368129LYSHG3H1.3550.0201
369129LYSCC176.4230.31
370129LYSCAC56.1680.31
371129LYSCBC32.7880.31
372129LYSNN118.4680.31
373130LYSHH7.9860.0201
374130LYSHAH4.3150.0201
375130LYSHB2H1.8500.0202
376130LYSHB3H1.7230.0202
377130LYSHG2H1.4240.0201
378130LYSHG3H1.4240.0201
379130LYSCC175.6240.31
380130LYSCAC56.3750.31
381130LYSCBC31.5270.31
382130LYSNN121.5830.31
383131ARGHH7.7880.0201
384131ARGHAH4.2890.0201
385131ARGHB2H1.6930.0202
386131ARGHB3H1.6010.0202
387131ARGHG2H1.4500.0201
388131ARGHD2H2.9750.0201
389131ARGHD3H2.9750.0201
390131ARGCC172.7350.31
391131ARGCAC56.3720.31
392131ARGCBC29.0040.31
393131ARGCGC24.6260.31
394131ARGCDC42.2590.31
395131ARGNN127.3760.31

Release date
2021-09-28
Citation
Diversity of Structural, Dynamic, and Environmental Effects Explain a Distinctive Functional Role of Transmembrane Domains in the Insulin Receptor Subfamily
Bershatsky, Y.V., Kuznetsov, A.S., Idiatullina, A.R., Bocharova, O.V., Dolotova, S.M., Gavrilenkova, A.A., Serova, O.V., Deyev, I.E., Rakitina, T.V., Zangieva, O.T., Pavlov, K.V., Batishchev, O.V., Britikov, V.V., Usanov, S.A., Arseniev, A.S., Efremov, R.G., Bocharov, E.V.
Int. J. Mol. Sci. (2023), 24, 3906-3906, PubMed 36835322 , DOI 10.3390/ijms24043906 ,
Related entities 1. Insulin-like growth factor 1 receptor (E.C.2.7.10.1), : 1 : 2 : 5 entities Detail
Interaction partners 1. Insulin-like growth factor 1 receptor (E.C.2.7.10.1), : 1 interactors Detail
Experiments performed 12 experiments Detail
Chemical shift validation 3 contents Detail
Keywords IRR, Insulin receptor-related receptor, PROTEIN, RECEPTOR, TRANSMEMBRANE DOMAIN, Transferase