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BMRB: 34721

Structure of a hybrid-type G-quadruplex with a snapback loop (hybrid 1R')
Authors
Jana, J., Vianney, Y.M., Schroeder, N., Weisz, K.
Assembly
DNA (5'-D(*(DG5)P*GP*CP*TP*AP*(BG)P*GP*GP*TP*CP*AP*GP*GP*GP*TP*GP*GP*GP*TP*CP*AP*(DG3))-3')
Entity
1. DNA (5'-D(*(DG5)P*GP*CP*TP*AP*(BG)P*GP*GP*TP*CP*AP*GP*GP*GP*TP*GP*GP*GP*TP*CP*AP*(DG3))-3') (polymer, Thiol state: not present), 22 monomers, 6991.336 Da Detail

XGCTAXGGTC AGGGTGGGTC AG


Formula weight
6991.336 Da
Source organism
synthetic construct
Exptl. method
solution NMR
Data set
assigned_chemical_shifts
Chem. Shift Complete
Sequence coverage: 90.9 %, Completeness: 63.7 %, Completeness (bb): 57.9 % Detail
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Polymer type: polydeoxyribonucleotide

Total1H
All63.7 % (121 of 190)63.7 % (121 of 190)
Suger, PO457.9 % (81 of 140)57.9 % (81 of 140)
Nucleobase80.0 % (40 of 50)80.0 % (40 of 50)
Aromatic90.0 % (36 of 40)90.0 % (36 of 40)
Methyl100.0 % (4 of 4)100.0 % (4 of 4)

1. entity 1

XGCTAXGGTC AGGGTGGGTC AG

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Sample

Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 303 K, pH 7.0, Details 0.3 mM DNA (5'-D(*(DG5)P*GP*CP*TP*AP*(BG)P*GP*GP*TP*CP*AP*GP*GP*GP*TP*GP*GP*GP*TP*CP*AP*(DG3))-3'), 90% H2O/10% D2O


#NameIsotope labelingTypeConcentration
1DNAnatural abundance0.3 mM

Release date
2022-04-26
Citation
Guiding the folding of G-quadruplexes through loop residue interactions
Jana, J., Vianney, Y.M., Schroeder, N., Weisz, K.
Nucleic Acids Res. (2022), 50, 7161-7175, PubMed 35758626 , DOI 10.1093/nar/gkac549 ,
Experiments performed 4 experiments Detail
Chemical shift validation 3 contents Detail
Keywords DNA, hybrid G-quadruplex, snapback loop