Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease
Polymer type: polypeptide(L)
Total | 1H | 13C | 15N | |
---|---|---|---|---|
All | 37.9 % (169 of 446) | 18.1 % (41 of 226) | 50.8 % (90 of 177) | 88.4 % (38 of 43) |
Backbone | 66.7 % (160 of 240) | 44.2 % (38 of 86) | 75.4 % (86 of 114) | 90.0 % (36 of 40) |
Sidechain | 12.5 % (30 of 240) | 2.1 % (3 of 140) | 25.8 % (25 of 97) | 66.7 % (2 of 3) |
Aromatic | 4.0 % (2 of 50) | 0.0 % (0 of 25) | 8.0 % (2 of 25) | |
Methyl | 8.7 % (4 of 46) | 8.7 % (2 of 23) | 8.7 % (2 of 23) |
1. entity 1
DAEFRHDSGY EVHHQKLVFF AEDVGSNKGA IIGLMVGGVVSolvent system 90% H2O/10% D2O, Pressure 1013.25 mbar, Temperature 281 K, pH 7.2, Details 10 mM no HEPES, 10 % D2 D2O, 100 uM no copper, 75 uM [U-100% 13C; U-100% 15N] amyloid beta, 90% H2O/10% D2O
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
1 | HEPES | no | 10 mM | |
2 | D2O | D2 | 10 % | |
3 | copper | no | 100 uM | |
4 | amyloid beta | [U-100% 13C; U-100% 15N] | 75 uM |