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TK9 NMR structure in DPC micelle
Authors
Ghosh, A., Bhunia, A.
Assembly
Self-Assembling Peptide From SARS-CoV E protein
Entity
1. Self-Assembling Peptide From SARS-CoV E protein (polymer, Thiol state: not present), 9 monomers, 1114.294 Da Detail

TVYVYSRVK


Formula weight
1114.294 Da
Source organism
Severe acute respiratory syndrome-related coronavirus
Exptl. method
solution NMR
Refine. method
DGSA-distance geometry simulated annealing
Data set
assigned_chemical_shifts
Chem. Shift Complete
Sequence coverage: 100.0 %, Completeness: 62.1 %, Completeness (bb): 50.0 % Detail

Polymer type: polypeptide(L)

Total1H
All62.1 % (36 of 58)62.1 % (36 of 58)
Backbone50.0 % (9 of 18)50.0 % (9 of 18)
Sidechain67.5 % (27 of 40)67.5 % (27 of 40)
Aromatic 0.0 % (0 of 8) 0.0 % (0 of 8)
Methyl100.0 % (7 of 7)100.0 % (7 of 7)

1. THR-VAL-TYR-VAL-TYR-SER-ARG-VAL-LYS

TVYVYSRVK

Sample

Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 310 K, pH 4.5, Details 1.0 mM TK9, 55.55 M H2O, 125 mM [U-100% 2H] DPC, 90% H2O/10% D2O


#NameIsotope labelingTypeConcentration
1TK9natural abundanceprotein1.0 mM
2DPC[U-100% 2H]125 mM
3H2Onatural abundancesolvent90 %
4D2O[U-2H]solvent10 %

Protein Blocks Logo
Calculated from 20 models in PDB: 5XER, Strand ID: A Detail


Release date
2017-06-05
Citation
Structural insights of a self-assembling 9-residue peptide from the C-terminal tail of the SARS corona virus E-protein in DPC and SDS micelles: A combined high and low resolution spectroscopic study
Ghosh, A., Bhattacharyya, D., Bhunia, A.
Biochim. Biophys. Acta (2017), 1860, 335-346, PubMed 29038024 , DOI 10.1016/j.bbamem.2017.10.015 ,
Experiments performed 2 experiments Detail
NMR combined restraints 4 contents Detail
Keywords CYANA 2.1