BMRB: 4596

Cystic fibrosis transmembrane conductance regulator: solution structures of peptides based on the Phe508 region, the most common site of disease-causing DeltaF508 mutation -- P26

Authors

Massiah, M.A., Ko, Y.H., Pedersen, P.L., Mildvan, A.S.

Assembly

cystic fibrosis transmembrane conductance regulator (CFTR)

Entity

1. cystic fibrosis transmembrane conductance regulator (CFTR) (polymer, Thiol state: not present), 26 monomers, 3050.486 Da Detail

MPGTIKENII FGVSYDEYRY RSVIKA

Formula weight

3050.486 Da

Source organism

Homo sapiens

Exptl. method

NMR

Refine. method

DISTANCE GEOMETRY

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 100.0 %, Completeness: 85.5 %, Completeness (bb): 98.1 % Detail

Download

• NMR-STAR v3.1 (partial)
• BMRB/XML (partial)
• CSV
• TSV

Polymer type: polypeptide(L)

	Total	1H
All	85.5 % (142 of 166)	85.5 % (142 of 166)
Backbone	98.1 % (52 of 53)	98.1 % (52 of 53)
Sidechain	79.6 % (90 of 113)	79.6 % (90 of 113)
Aromatic	82.4 % (14 of 17)	82.4 % (14 of 17)
Methyl	100.0 % (14 of 14)	100.0 % (14 of 14)

1. PROTEIN (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR))

MPGTIKENII FGVSYDEYRY RSVIKA

Show sample condition

Sample

Pressure 1 atm, Temperature 298 K, pH 4.0

#	Name	Isotope labeling	Type	Concentration
1	PROTEIN (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR))			0.0 ~ 0.0 mM
2	Trifluroethanol	[U-2H]		43 %

Hide sample codition

Protein Blocks Logo

Calculated from 13 models in PDB: 1CKX, Strand ID: A Detail

---

Release date

2000-12-03

Citation

Cystic fibrosis transmembrane conductance regulator: solution structures of peptides based on the Phe508 region, the most common site of disease-causing DeltaF508 mutation
Massiah, M.A., Ko, Y.H., Pedersen, P.L., Mildvan, A.S.
Biochemistry (1999), 38, 7453-7461, PubMed 10360942 , DOI 10.1021/bi9903603 , Abstract

Related entities 1. cystic fibrosis transmembrane conductance regulator (CFTR), : 1 : 29 : 19 : 7 : 180 entities Detail

Interaction partners 1. cystic fibrosis transmembrane conductance regulator (CFTR), : 29 interactors Detail

Experiments performed 3 experiments Detail