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Found 1 Document (1.763 seconds)

BMRB: 4779


4779
1PLO
Backbone sequential resonance assignments of the ligand binding domain of the human TGF-beta type II receptor
Authors
Hinck, A.P.
Assembly
Ligand Binding Domain of the Human TGF-beta type II receptor
Entity
1. Ligand Binding Domain of the Human TGF-beta type II receptor (polymer, Thiol state: free and disulfide bound), 122 monomers, 13795.48 Da Detail

VTDNAGAVKF PQLCKFCDVR FSTCDNQKSC MSNCSITSIC EKPQEVCVAV WRKNDENITL ETVCHDPKLP YHDFILEDAA SPKCIMKEKK KPGETFFMCS CSSDECNDNI IFSEEYNTSN PD


Formula weight
13795.48 Da
Entity Connection
disulfide 4 Detail
IDTypeValue orderAtom ID 1Atom ID 2
1disulfidesing1:CYS99:SG1:CYS84:SG
2disulfidesing1:CYS101:SG1:CYS106:SG
3disulfidesing1:CYS47:SG1:CYS14:SG
4disulfidesing1:CYS64:SG1:CYS40:SG

Source organism
Homo sapiens
Exptl. method
NMR
Refine. method
substructure distance geometry, full structure distance geometry-simulated annealing;
Data set
assigned_chemical_shifts
Chem. Shift Complete
Sequence coverage: 95.9 %, Completeness: 84.6 %, Completeness (bb): 93.9 % Detail
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Polymer type: polypeptide(L)

Total1H13C15N
All84.6 % (1183 of 1398)81.9 % (598 of 730)88.7 % (479 of 540)82.8 % (106 of 128)
Backbone93.9 % (674 of 718)92.5 % (221 of 239)95.6 % (348 of 364)91.3 % (105 of 115)
Sidechain78.0 % (624 of 800)76.8 % (377 of 491)83.1 % (246 of 296) 7.7 % (1 of 13)
Aromatic41.5 % (44 of 106)50.9 % (27 of 53)30.8 % (16 of 52)100.0 % (1 of 1)
Methyl95.8 % (92 of 96)95.8 % (46 of 48)95.8 % (46 of 48)

1. TGF-bet type II receptor

VTDNAGAVKF PQLCKFCDVR FSTCDNQKSC MSNCSITSIC EKPQEVCVAV WRKNDENITL ETVCHDPKLP YHDFILEDAA SPKCIMKEKK KPGETFFMCS CSSDECNDNI IFSEEYNTSN PD

Show sample condition
Sample

Temperature 300 (±0.5) K, pH 5.50 (±0.05)


#NameIsotope labelingTypeConcentration
1TGF-bet type II receptor[U-99% 13C; U-99% 15N]0.5 ~ 2.0 mM

LACS Plot; CA
Referencing offset: -0.14 ppm, Outliers: 2 Detail
LACS Plot; CB
Referencing offset: -0.14 ppm, Outliers: 2 Detail
LACS Plot; HA
Referencing offset: -0.03 ppm, Outliers: 2 Detail
LACS Plot; CO
Referencing offset: 0.69 ppm, Outliers: 2 Detail
Protein Blocks Logo
Calculated from 10 models in PDB: 1PLO, Strand ID: A Detail

Release date
2000-12-17
Citation
Letter to the Editor: Sequential resonance assignments of the extracellular ligand binding domain of the human TGF-b type II receptor
Hinck, A.P., Walker, K.P., Martin, N.R., Deep, S., Hinck, C.S., Freedberg, D.I.
J. Biomol. NMR (2000), 18, 369-370
Related entities 1. Ligand Binding Domain of the Human TGF-beta type II receptor, : 1 : 10 : 13 entities Detail
More details for 24 related entities
Interaction partners 1. Ligand Binding Domain of the Human TGF-beta type II receptor, : 28 interactors Detail
More details for 28 interactors identified by 15 citations
Experiments performed 9 experiments Detail
nullKeywords TGF, ligand-receptor, NMR