BMRB: 4990

Solution structure of betacellulin, a new member of EGF-family ligands.

Authors

Miura, K., Doura, H., Aizawa, T., Tada, H., Seno, M., Yamada, H., Kawano, K.

Assembly

Betacellulin-2

Entity

1. Betacellulin-2 (polymer, Thiol state: all disulfide bound), 50 monomers, 5904.788 Da Detail

RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY

Formula weight

5904.788 Da

Entity Connection

disulfide 3 Detail

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ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	1:CYS8:SG	1:CYS21:SG
2	disulfide	sing	1:CYS16:SG	1:CYS32:SG
3	disulfide	sing	1:CYS34:SG	1:CYS43:SG

Source organism

Homo sapiens

Exptl. method

NMR

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 96.0 %, Completeness: 81.3 %, Completeness (bb): 96.1 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	81.3 % (257 of 316)	81.3 % (257 of 316)
Backbone	96.1 % (98 of 102)	96.1 % (98 of 102)
Sidechain	74.3 % (159 of 214)	74.3 % (159 of 214)
Aromatic	68.6 % (24 of 35)	68.6 % (24 of 35)
Methyl	100.0 % (17 of 17)	100.0 % (17 of 17)

1. Betacellulin

RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY

Show sample condition

Sample

Temperature 298 (±1) K, pH 3.5 (±0.2)

#	Name	Isotope labeling	Type	Concentration
1	Betacellulin			2.0 mM

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Release date

2001-04-16

Citation

Solution structure of betacellulin, a new member of EGF-family ligands
Miura, K., Doura, H., Aizawa, T., Tada, H., Seno, M., Yamada, H., Kawano, K.
Biochem. Biophys. Res. Commun. (2002), 294, 1040-1046, PubMed 12074582 , DOI 10.1016/S0006-291X(02)00585-5 , Abstract

Entries sharing articles Swiss-Prot: 1 entries Detail

Related entities 1. Betacellulin-2, : 1 : 3 : 2 : 150 entities Detail

Interaction partners 1. Betacellulin-2, : 5 interactors Detail

Experiments performed 3 experiments Detail

Chemical shift validation 3 contents Detail