BMRB: 51600

BIR2 domain of Xiap

Authors

Favier, A., Pellegrini, E.

Assembly

Xiap-BIR2

Entity

1. Xiap-BIR2 (polymer, Thiol state: all other bound), 117 monomers, 13560.94 Da Detail

RDHFALDRPS ETHADYLLRT GQVVDISDTI YPRNPAMYSE EARLKSFQNW PDYAHLTPRE LASAGLYYTG IGDQVQCFAC GGKLKNWEPG DRAWSEHRRH FPNCFFVLGR NLNIRSE

Formula weight

13560.94 Da

Source organism

Homo sapiens

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chemcal Shifts

¹H: 84, ¹³C: 154, ¹⁵N: 84 assignments Detail

Download

• NMR-STAR v3.1 (partial)
• BMRB/XML (partial)
• CSV
• TSV

ID	Entity ID	Seq ID	Comp ID	Atom ID	Atom type	Val	Val err	Ambig. code
1	1	4	PHE	H	H	8.002441	0.003309745	1
2	1	4	PHE	CA	C	57.62356	0	1
3	1	4	PHE	CB	C	39.31641	0	1
4	1	4	PHE	N	N	120.7111	0.03691698	1
5	1	5	ALA	H	H	8.069014	0.002080318	1
6	1	5	ALA	CA	C	52.35133	0	1
7	1	5	ALA	CB	C	19.34196	0	1
8	1	5	ALA	N	N	124.9410	0.03074822	1
9	1	6	LEU	H	H	8.108802	0.002318630	1
10	1	6	LEU	CA	C	55.17580	0	1
11	1	6	LEU	CB	C	42.32468	0	1
12	1	6	LEU	N	N	120.8456	0.2159577	1
13	1	7	ASP	H	H	8.293122	0.002694551	1
14	1	7	ASP	CA	C	54.16436	0	1
15	1	7	ASP	CB	C	41.04398	0	1
16	1	7	ASP	N	N	120.2296	0.02584256	1
17	1	8	ARG	H	H	8.062961	0.002760348	1
18	1	8	ARG	CA	C	53.88485	0	1
19	1	8	ARG	CB	C	30.33733	0	1
20	1	8	ARG	N	N	121.2385	0.02062302	1
21	1	10	SER	H	H	8.423469	0.002557324	1
22	1	10	SER	CA	C	58.43585	0	1
23	1	10	SER	N	N	115.7863	0.01706134	1
24	1	11	GLU	H	H	8.376252	0.003573541	1
25	1	11	GLU	CA	C	56.46728	0	1
26	1	11	GLU	N	N	123.1551	0.02809431	1
27	1	12	THR	H	H	8.503605	0.01771969	1
28	1	12	THR	CA	C	61.67142	0	1
29	1	12	THR	CB	C	70.24694	0	1
30	1	12	THR	N	N	115.2424	0.06904501	1
31	1	14	ALA	H	H	8.331829	0.0004260576	1
32	1	14	ALA	CA	C	54.33127	0	1
33	1	14	ALA	N	N	122.3439	0.02343968	1
34	1	15	ASP	H	H	8.217864	0.009537529	1
35	1	15	ASP	CA	C	56.16803	0	1
36	1	15	ASP	CB	C	40.69012	0	1
37	1	15	ASP	N	N	118.9384	0.03449873	1
38	1	16	TYR	H	H	8.129929	0.005522615	1
39	1	16	TYR	CA	C	60.13417	0	1
40	1	16	TYR	CB	C	38.04229	0	1
41	1	16	TYR	N	N	121.6388	0.1642591	1
42	1	17	LEU	H	H	8.130495	0.005009388	1
43	1	17	LEU	CA	C	56.64635	0	1
44	1	17	LEU	CB	C	41.70182	0	1
45	1	17	LEU	N	N	121.7510	0.04944832	1
46	1	18	LEU	H	H	7.771367	0.01061937	1
47	1	18	LEU	CA	C	55.88549	0	1
48	1	18	LEU	CB	C	42.089	0	1
49	1	18	LEU	N	N	119.9891	0.2309638	1
50	1	20	THR	H	H	7.851985	0.0004642871	1
51	1	20	THR	CA	C	62.16244	0	1
52	1	20	THR	N	N	110.1949	0.02371223	1
53	1	21	GLY	H	H	8.051452	0.005158097	1
54	1	21	GLY	CA	C	45.78495	0	1
55	1	21	GLY	N	N	110.6652	0.03673041	1
56	1	22	GLN	H	H	8.107221	0.003138834	1
57	1	22	GLN	CA	C	55.73686	0	1
58	1	22	GLN	CB	C	30.12040	0	1
59	1	22	GLN	N	N	119.3078	0.03148972	1
60	1	23	VAL	H	H	8.109502	0.005552679	1
61	1	23	VAL	CA	C	62.15019	0	1
62	1	23	VAL	CB	C	32.90283	0	1
63	1	23	VAL	N	N	120.6435	0.1043242	1
64	1	24	VAL	H	H	8.220087	0.002891239	1
65	1	24	VAL	CA	C	62.00215	0	1
66	1	24	VAL	CB	C	33.03111	0	1
67	1	24	VAL	N	N	123.6791	0.02621312	1
68	1	25	ASP	H	H	8.448491	0.004624984	1
69	1	25	ASP	CA	C	53.93543	0	1
70	1	25	ASP	CB	C	41.68601	0	1
71	1	25	ASP	N	N	124.6368	0.03003701	1
72	1	26	ILE	H	H	8.216751	0.004576389	1
73	1	26	ILE	CA	C	61.47912	0	1
74	1	26	ILE	CB	C	38.59967	0	1
75	1	26	ILE	N	N	121.4234	0.03234371	1
76	1	27	SER	H	H	8.457023	0.003760463	1
77	1	27	SER	CA	C	59.02310	0	1
78	1	27	SER	CB	C	63.75853	0	1
79	1	27	SER	N	N	119.0518	0.02680085	1
80	1	28	ASP	H	H	8.269032	0.003289800	1
81	1	28	ASP	CA	C	54.59905	0	1
82	1	28	ASP	CB	C	41.26102	0	1
83	1	28	ASP	N	N	122.1340	0.03565818	1
84	1	29	THR	H	H	8.016246	0.002166415	1
85	1	29	THR	CA	C	62.21905	0	1
86	1	29	THR	CB	C	69.86972	0	1
87	1	29	THR	N	N	114.0458	0.03550921	1
88	1	30	ILE	H	H	7.782977	0.001232430	1
89	1	30	ILE	CA	C	60.48191	0	1
90	1	30	ILE	CB	C	38.56438	0	1
91	1	30	ILE	N	N	120.9184	0.01605459	1
92	1	31	TYR	H	H	8.041889	0.0007932572	1
93	1	31	TYR	CA	C	55.55758	0	1
94	1	31	TYR	N	N	123.7429	0.02498506	1
95	1	36	ALA	H	H	7.619694	0.004593528	1
96	1	36	ALA	CA	C	53.96752	0	1
97	1	36	ALA	CB	C	17.98684	0	1
98	1	36	ALA	N	N	119.0762	0.02466826	1
99	1	37	MET	H	H	7.205100	0.003377669	1
100	1	37	MET	CA	C	52.44833	0	1
101	1	37	MET	CB	C	33.64359	0	1
102	1	37	MET	N	N	116.1266	0.02556934	1
103	1	38	TYR	H	H	7.031408	0.004312223	1
104	1	38	TYR	CA	C	59.34913	0	1
105	1	38	TYR	CB	C	39.00526	0	1
106	1	38	TYR	N	N	119.4545	0.03598150	1
107	1	39	SER	H	H	7.770964	0.0009686230	1
108	1	39	SER	CA	C	55.78358	0	1
109	1	39	SER	CB	C	64.58424	0	1
110	1	39	SER	N	N	113.5866	0.02539115	1
111	1	40	GLU	H	H	9.084772	0.006408342	1
112	1	40	GLU	CA	C	60.53512	0	1
113	1	40	GLU	N	N	127.9152	0.04515703	1
114	1	41	GLU	H	H	8.616282	0.001630249	1
115	1	41	GLU	CA	C	59.81076	0	1
116	1	41	GLU	CB	C	29.36212	0	1
117	1	41	GLU	N	N	117.7646	0.02510977	1
118	1	42	ALA	H	H	7.459502	0.002081588	1
119	1	42	ALA	CA	C	54.96080	0	1
120	1	42	ALA	CB	C	18.34796	0	1
121	1	42	ALA	N	N	122.4981	0.02807209	1
122	1	43	ARG	H	H	7.753291	0.002674831	1
123	1	43	ARG	CA	C	60.03741	0	1
124	1	43	ARG	CB	C	30.11569	0	1
125	1	43	ARG	N	N	116.8785	0.03159432	1
126	1	44	LEU	H	H	9.073400	0.002063041	1
127	1	44	LEU	CA	C	58.87478	0	1
128	1	44	LEU	CB	C	41.77016	0	1
129	1	44	LEU	N	N	123.6881	0.02541378	1
130	1	45	LYS	H	H	7.858763	0.004025717	1
131	1	45	LYS	CA	C	58.77715	0	1
132	1	45	LYS	CB	C	32.47236	0	1
133	1	45	LYS	N	N	119.0713	0.02649819	1
134	1	46	SER	H	H	7.561839	0.005498262	1
135	1	46	SER	CA	C	61.07707	0	1
136	1	46	SER	CB	C	63.47300	0	1
137	1	46	SER	N	N	114.1529	0.06848075	1
138	1	47	PHE	H	H	7.525839	0.003990393	1
139	1	47	PHE	CA	C	60.25622	0	1
140	1	47	PHE	CB	C	37.59826	0	1
141	1	47	PHE	N	N	119.6144	0.01702694	1
142	1	48	GLN	H	H	7.504573	0.003884899	1
143	1	48	GLN	CA	C	58.86828	0	1
144	1	48	GLN	CB	C	28.76978	0	1
145	1	48	GLN	N	N	123.0180	0.02800924	1
146	1	55	HIS	H	H	8.007763	0.002943516	1
147	1	55	HIS	CA	C	57.98529	0	1
148	1	55	HIS	CB	C	31.55662	0	1
149	1	55	HIS	N	N	116.7339	0.03658697	1
150	1	56	LEU	H	H	7.339674	0.002573664	1
151	1	56	LEU	CA	C	54.39109	0	1
152	1	56	LEU	CB	C	44.71066	0	1
153	1	56	LEU	N	N	118.9904	0.02634991	1
154	1	57	THR	H	H	8.331384	0.001650479	1
155	1	57	THR	CA	C	58.56152	0	1
156	1	57	THR	CB	C	70.07537	0	1
157	1	57	THR	N	N	109.4320	0.03409522	1
158	1	59	ARG	H	H	7.900883	0.001115875	1
159	1	59	ARG	CA	C	59.22462	0	1
160	1	59	ARG	CB	C	29.44708	0	1
161	1	59	ARG	N	N	113.3159	0.03118636	1
162	1	60	GLU	H	H	7.325542	0.0007767375	1
163	1	60	GLU	CA	C	59.13686	0	1
164	1	60	GLU	CB	C	28.94901	0	1
165	1	60	GLU	N	N	119.8169	0.01843471	1
166	1	61	LEU	H	H	7.387772	0.002295530	1
167	1	61	LEU	CA	C	58.61945	0	1
168	1	61	LEU	CB	C	41.94665	0	1
169	1	61	LEU	N	N	119.8580	0.02462258	1
170	1	62	ALA	H	H	9.084585	0.002669128	1
171	1	62	ALA	CA	C	54.89053	0	1
172	1	62	ALA	CB	C	18.16199	0	1
173	1	62	ALA	N	N	121.3861	0.02191396	1
174	1	63	SER	H	H	7.996366	0.004846099	1
175	1	63	SER	CA	C	61.24369	0	1
176	1	63	SER	CB	C	63.08016	0	1
177	1	63	SER	N	N	116.8098	0.02345117	1
178	1	64	ALA	H	H	7.193734	0.005210917	1
179	1	64	ALA	CA	C	51.43065	0	1
180	1	64	ALA	CB	C	18.18617	0	1
181	1	64	ALA	N	N	120.7824	0.02848133	1
182	1	65	GLY	H	H	7.562289	0.001328383	1
183	1	65	GLY	CA	C	45.53573	0	1
184	1	65	GLY	N	N	105.1784	0.02336154	1
185	1	66	LEU	H	H	7.627259	0.002599274	1
186	1	66	LEU	CA	C	53.39000	0	1
187	1	66	LEU	CB	C	42.36121	0	1
188	1	66	LEU	N	N	118.9173	0.03345401	1
189	1	67	TYR	H	H	8.991098	0.001132809	1
190	1	67	TYR	CA	C	54.51482	0	1
191	1	67	TYR	CB	C	42.26391	0	1
192	1	67	TYR	N	N	115.9555	0.02270224	1
193	1	71	ILE	H	H	7.001480	0.002244416	1
194	1	71	ILE	CA	C	59.21821	0	1
195	1	71	ILE	CB	C	40.15777	0	1
196	1	71	ILE	N	N	119.4222	0.03412593	1
197	1	72	GLY	H	H	8.955500	0.001053040	1
198	1	72	GLY	CA	C	47.34776	0	1
199	1	72	GLY	N	N	114.5566	0.03062077	1
200	1	73	ASP	H	H	8.425108	0.002986296	1
201	1	73	ASP	CA	C	51.99702	0	1
202	1	73	ASP	CB	C	41.01707	0	1
203	1	73	ASP	N	N	127.7643	0.02090483	1
204	1	74	GLN	H	H	8.742882	0.002968920	1
205	1	74	GLN	CA	C	56.39814	0	1
206	1	74	GLN	CB	C	30.61450	0	1
207	1	74	GLN	N	N	117.7926	0.02239130	1
208	1	75	VAL	H	H	9.573808	0.006529851	1
209	1	75	VAL	CA	C	58.37870	0	1
210	1	75	VAL	CB	C	34.57878	0	1
211	1	75	VAL	N	N	122.9553	0.03363597	1
212	1	76	GLN	H	H	8.740673	0.003606797	1
213	1	76	GLN	CA	C	52.80747	0	1
214	1	76	GLN	CB	C	32.43224	0	1
215	1	76	GLN	N	N	120.1820	0.02462395	1
216	1	77	CYS	H	H	8.224626	0.0007356231	1
217	1	77	CYS	CA	C	57.93779	0	1
218	1	77	CYS	N	N	123.9867	0.02388263	1
219	1	78	PHE	H	H	8.421246	0.003109545	1
220	1	78	PHE	CA	C	60.33552	0	1
221	1	78	PHE	CB	C	39.85497	0	1
222	1	78	PHE	N	N	128.8923	0.01336396	1
223	1	79	ALA	H	H	9.235412	0.005779784	1
224	1	79	ALA	CA	C	54.25135	0	1
225	1	79	ALA	CB	C	20.42217	0	1
226	1	79	ALA	N	N	129.8712	0.02757645	1
227	1	80	CYS	H	H	8.840296	0.003935100	1
228	1	80	CYS	CA	C	58.98432	0	1
229	1	80	CYS	CB	C	32.38515	0	1
230	1	80	CYS	N	N	117.8084	0.02565164	1
231	1	81	GLY	H	H	7.132260	0.001488417	1
232	1	81	GLY	CA	C	45.71530	0	1
233	1	81	GLY	N	N	110.1966	0.03408106	1
234	1	82	GLY	H	H	9.054501	0.0005590523	1
235	1	82	GLY	CA	C	44.97793	0	1
236	1	82	GLY	N	N	115.7568	0.01734685	1
237	1	83	LYS	H	H	7.997342	0.0006907308	1
238	1	83	LYS	CA	C	54.87438	0	1
239	1	83	LYS	CB	C	35.52811	0	1
240	1	83	LYS	N	N	121.4527	0.02853863	1
241	1	84	LEU	H	H	8.388966	0.003124071	1
242	1	84	LEU	CA	C	53.97003	0	1
243	1	84	LEU	CB	C	47.16205	0	1
244	1	84	LEU	N	N	120.9901	0.02892478	1
245	1	85	LYS	H	H	8.039867	0.0005482324	1
246	1	85	LYS	CA	C	54.59120	0	1
247	1	85	LYS	CB	C	35.89642	0	1
248	1	85	LYS	N	N	118.3641	0.03675110	1
249	1	90	GLY	H	H	8.746458	0.001728867	1
250	1	90	GLY	CA	C	44.98113	0	1
251	1	90	GLY	N	N	113.4271	0.05810455	1
252	1	91	ASP	H	H	8.141838	0.004939334	1
253	1	91	ASP	CA	C	55.33867	0	1
254	1	91	ASP	CB	C	42.42930	0	1
255	1	91	ASP	N	N	122.4609	0.001538430	1
256	1	92	ARG	H	H	8.902851	0.001562884	1
257	1	92	ARG	CA	C	53.66637	0	1
258	1	92	ARG	CB	C	32.78437	0	1
259	1	92	ARG	N	N	117.9021	0.02542302	1
260	1	93	ALA	H	H	8.531933	0.005318344	1
261	1	93	ALA	CA	C	55.76895	0	1
262	1	93	ALA	CB	C	20.48368	0	1
263	1	93	ALA	N	N	126.3496	0.02924278	1
264	1	94	TRP	H	H	9.779694	0.001004946	1
265	1	94	TRP	CA	C	61.16166	0	1
266	1	94	TRP	CB	C	29.54742	0	1
267	1	94	TRP	N	N	117.4104	0.02133040	1
268	1	95	SER	H	H	7.042690	0.004614291	1
269	1	95	SER	CA	C	61.26711	0	1
270	1	95	SER	CB	C	62.65885	0	1
271	1	95	SER	N	N	110.6942	0.02615854	1
272	1	96	GLU	H	H	8.259615	0.005592689	1
273	1	96	GLU	CA	C	58.50563	0	1
274	1	96	GLU	CB	C	30.00748	0	1
275	1	96	GLU	N	N	119.4629	0.05522441	1
276	1	97	HIS	H	H	8.520407	0.004196840	1
277	1	97	HIS	CA	C	58.13745	0	1
278	1	97	HIS	CB	C	29.97919	0	1
279	1	97	HIS	N	N	120.0289	0.04770755	1
280	1	98	ARG	H	H	8.191378	0.002920925	1
281	1	98	ARG	CA	C	58.81481	0	1
282	1	98	ARG	CB	C	30.17289	0	1
283	1	98	ARG	N	N	115.5444	0.02817725	1
284	1	99	ARG	H	H	7.854710	0.005702073	1
285	1	99	ARG	CA	C	58.74595	0	1
286	1	99	ARG	CB	C	30.81777	0	1
287	1	99	ARG	N	N	117.1677	0.02834731	1
288	1	103	ASN	H	H	8.381952	0.001000500	1
289	1	103	ASN	CA	C	52.10958	0	1
290	1	103	ASN	CB	C	38.82739	0	1
291	1	103	ASN	N	N	113.1233	0.03031646	1
292	1	104	CYS	H	H	7.598043	0.004022841	1
293	1	104	CYS	CA	C	59.65866	0	1
294	1	104	CYS	CB	C	30.17298	0	1
295	1	104	CYS	N	N	124.5930	0.02560800	1
296	1	105	PHE	H	H	8.762950	0.001928866	1
297	1	105	PHE	CA	C	60.56237	0	1
298	1	105	PHE	CB	C	37.97378	0	1
299	1	105	PHE	N	N	128.2661	0.01553771	1
300	1	106	PHE	H	H	8.661231	0.002111117	1
301	1	106	PHE	CA	C	61.26998	0	1
302	1	106	PHE	CB	C	40.50731	0	1
303	1	106	PHE	N	N	127.3205	0.02775718	1
304	1	107	VAL	H	H	7.668038	0.002836424	1
305	1	107	VAL	CA	C	65.03572	0	1
306	1	107	VAL	CB	C	31.98078	0	1
307	1	107	VAL	N	N	122.5552	0.04402884	1
308	1	108	LEU	H	H	8.205706	0.001611552	1
309	1	108	LEU	CA	C	56.28494	0	1
310	1	108	LEU	CB	C	42.63694	0	1
311	1	108	LEU	N	N	118.0358	0.02675210	1
312	1	109	GLY	H	H	7.765953	0.001171644	1
313	1	109	GLY	CA	C	45.98011	0	1
314	1	109	GLY	N	N	107.0645	0.02078140	1
315	1	114	ILE	H	H	7.893697	0.003117340	1
316	1	114	ILE	CA	C	60.88551	0	1
317	1	114	ILE	CB	C	38.84365	0	1
318	1	114	ILE	N	N	120.1059	0.02969277	1
319	1	115	ARG	H	H	8.437487	0.003120594	1
320	1	115	ARG	CA	C	55.88400	0	1
321	1	115	ARG	CB	C	30.94806	0	1
322	1	115	ARG	N	N	125.4240	0.04295004	1

Release date

2022-08-28

Citation

Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface
Lethier, M., Hons, M., Favier, A., Brutscher, B., Boeri Erba, E., Cusack, S., Pellegrini, E.
Life Sci. Alliance (2023), 6, e202201784-e202201784, PubMed 37673444 , DOI 10.26508/lsa.202201784 , Abstract

Related entities 1. Xiap-BIR2, : 1 : 1 : 5 : 12 entities Detail

Interaction partners 1. Xiap-BIR2, : 74 interactors Detail

Experiments performed 7 experiments Detail

Chemical shift validation 3 contents Detail