Native State Hydrogen Exchange Study of Suppressor and Pathogenic Variants of Transthyretin
MGPTGTGESK CPLMVKVLDA VRGSPAINVA VHVFRKAADD TWEPFASGKT SESGELHGLT TEEEFVEGIY KVEIDTKSYW KALGISPFHE HAEVVFTAND SGPRRYTIAA LLSPYSYSTT AVVTNPKE
Polymer type: polypeptide(L)
Total | 1H | 13C | 15N | |
---|---|---|---|---|
All | 29.1 % (416 of 1429) | 21.8 % (159 of 731) | 23.7 % (136 of 573) | 96.8 % (121 of 125) |
Backbone | 50.4 % (379 of 752) | 49.2 % (127 of 258) | 35.6 % (133 of 374) | 99.2 % (119 of 120) |
Sidechain | 4.9 % (39 of 795) | 6.8 % (32 of 473) | 1.6 % (5 of 317) | 40.0 % (2 of 5) |
Aromatic | 3.1 % (4 of 130) | 3.1 % (2 of 65) | 0.0 % (0 of 63) | 100.0 % (2 of 2) |
Methyl | 4.2 % (6 of 144) | 5.6 % (4 of 72) | 2.8 % (2 of 72) |
1. Transthyretin
MGPTGTGESK CPLMVKVLDA VRGSPAINVA VHVFRKAADD TWEPFASGKT SESGELHGLT TEEEFVEGIY KVEIDTKSYW KALGISPFHE HAEVVFTAND SGPRRYTIAA LLSPYSYSTT AVVTNPKETemperature 298 (±1) K, pH 5.75 (±0.1)
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
1 | Transthyretin | 0.3 ~ 1.2 mM |