Native State Hydrogen Exchange Study of Suppressor and Pathogenic Variants of Transthyretin
MGPTGTGESK CPLMVKVLDA VRGSPAINVA VHVFRKAADD TWEPFASGKT SESGEPHGLT TEEEFVEGIY KVEIDTKSYW KALGISPFHE HAEVVFTAND SGPRRYTIAA LLSPYSYSTT AVVTNPKE
Polymer type: polypeptide(L)
Total | 1H | 13C | 15N | |
---|---|---|---|---|
All | 31.6 % (451 of 1427) | 23.5 % (172 of 731) | 28.0 % (160 of 572) | 96.0 % (119 of 124) |
Backbone | 52.3 % (392 of 750) | 50.2 % (129 of 257) | 39.0 % (146 of 374) | 98.3 % (117 of 119) |
Sidechain | 9.3 % (74 of 795) | 9.1 % (43 of 474) | 9.2 % (29 of 316) | 40.0 % (2 of 5) |
Aromatic | 3.1 % (4 of 130) | 3.1 % (2 of 65) | 0.0 % (0 of 63) | 100.0 % (2 of 2) |
Methyl | 6.4 % (9 of 140) | 5.7 % (4 of 70) | 7.1 % (5 of 70) |
1. Transthyretin
MGPTGTGESK CPLMVKVLDA VRGSPAINVA VHVFRKAADD TWEPFASGKT SESGEPHGLT TEEEFVEGIY KVEIDTKSYW KALGISPFHE HAEVVFTAND SGPRRYTIAA LLSPYSYSTT AVVTNPKETemperature 298 (±1) K, pH 7 (±0.1)
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
1 | Transthyretin | [U-C13; U-N15] | 0.3 ~ 1.5 mM | |
2 | D2O | 100 % |