The loss of stability of a naturally occurring ATP7A mutant is the cause of Menkes disease
Polymer type: polypeptide(L)
Total | 1H | 15N | |
---|---|---|---|
All | 81.7 % (416 of 509) | 80.0 % (348 of 435) | 91.9 % (68 of 74) |
Backbone | 91.6 % (208 of 227) | 91.6 % (141 of 154) | 91.8 % (67 of 73) |
Sidechain | 73.8 % (208 of 282) | 73.7 % (207 of 281) | 100.0 % (1 of 1) |
Aromatic | 42.9 % (9 of 21) | 42.9 % (9 of 21) | |
Methyl | 96.2 % (51 of 53) | 96.2 % (51 of 53) |
1. Copper-transporting ATPase 1
MGDGVLELVV RGMTCASCVH KIESSLTKHR GILYCSVALA TNKAHIKYDP EIIGPRDIIH TIESLGFEAS LVKIEPressure 1 atm, Temperature 298 K, pH 7
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
1 | Copper-transporting ATPase 1 | [U-15N] | 0.8 mM | |
2 | DTT | 5 mM | ||
3 | phosphate buffer | 100 mM | ||
4 | H2O | 90 % | ||
5 | D2O | 10 % |