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Solution structure of [Sec2,8]-ImI
Authors
Armishaw, C.J.
Assembly
Alpha-conotoxin ImI
Entity
1. Alpha-conotoxin ImI (polymer, Thiol state: all disulfide bound), 12 monomers, 1450.367 Da Detail

GXCSDPRXAW RC


Formula weight
1450.367 Da
Entity Connection
diselenide 1, disulfide 1 Detail

IDTypeValue orderAtom ID 1Atom ID 2
1diselenidesing1:SEC2:SEG1:SEC8:SEG
2disulfidesing1:CYS3:SG1:CYS12:SG

Exptl. method
NMR
Data set
assigned_chemical_shifts
Chem. Shift Complete
Sequence coverage: 83.3 %, Completeness: 87.7 %, Completeness (bb): 95.0 % Detail

Polymer type: polypeptide(L)

Total1H
All87.7 % (50 of 57)87.7 % (50 of 57)
Backbone95.0 % (19 of 20)95.0 % (19 of 20)
Sidechain83.8 % (31 of 37)83.8 % (31 of 37)
Aromatic33.3 % (2 of 6)33.3 % (2 of 6)
Methyl100.0 % (1 of 1)100.0 % (1 of 1)

1. Alpha-conotoxin ImI

GXCSDPRXAW RC

Sample

Pressure 1 atm, Temperature 290 K, pH 3.5


#NameIsotope labelingTypeConcentration
1Alpha-conotoxin ImI1 mM
2D2O90 %
3H2O10 %

Release date
2005-11-28
Citation
Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists
Armishaw, C.J., Daly, N.L., Nevin, S.T., Adams, D.J., Craik, D.J., Alewood, P.F.
J. Biol. Chem. (2006), 281, 14136-14143, PubMed 16500898 , DOI 10.1074/jbc.M512419200 ,
Related entities 1. Alpha-conotoxin ImI, : 1 : 7 : 4 entities Detail
Interaction partners 1. Alpha-conotoxin ImI, : 1 interactors Detail
Experiments performed 4 experiments Detail
nullKeywords conotoxin, diselenide bond, disulfide bond, helix