BMRB: 30946

NMR Solution Structure of hGal(2-12)KK, a solubility-tagged truncation of the human neuropeptide galanin

Authors

Kraichely, K.N., Clinkscales, S.E., Parnham, S., Giuliano, M.W.

Assembly

Galanin

Entity

1. Galanin (polymer, Thiol state: not present), 14 monomers, 1448.688 Da Detail

WTLNSAGYLL GKKX

Formula weight

1448.688 Da

Source organism

Homo sapiens

Exptl. method

solution NMR

Data set

assigned_chemical_shifts, spectral_peak_list

Chem. Shift Complete

Sequence coverage: 92.9 %, Completeness: 96.3 %, Completeness (bb): 89.3 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	96.3 % (79 of 82)	96.3 % (79 of 82)
Backbone	89.3 % (25 of 28)	89.3 % (25 of 28)
Sidechain	100.0 % (54 of 54)	100.0 % (54 of 54)
Aromatic	100.0 % (10 of 10)	100.0 % (10 of 10)
Methyl	100.0 % (8 of 8)	100.0 % (8 of 8)

1. entity 1

WTLNSAGYLL GKKX

Show sample condition

Sample

Solvent system 95% H2O/5% D2O, Pressure 1 atm, Temperature 298 K, pH 4.6, Details 5 mM hGal(2-12)KK, 4.14 mM D3 sodium acetate, 5.86 mM D4 acetic acid, 95% H2O/5% D2O

#	Name	Isotope labeling	Type	Concentration
1	hGal(2-12)KK	natural abundance		5 mM
2	sodium acetate	D3		4.14 mM
3	acetic acid	D4		5.86 mM

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Release date

2021-09-25

Citation

Minimal Increments of Hydrophobic Collapse within the N-Terminus of the Neuropeptide Galanin
Kraichely, K.N., Clinkscales, S.E., Hendy, C.M., Mendoza, E.A., Parnham, S., Giuliano, M.W.
Biochemistry (2022), 61, 1151-1166, PubMed 35622960 , DOI 10.1021/acs.biochem.2c00141 , Abstract

Entries sharing articles BMRB: 2 entries Detail

Related entities 1. Galanin, : 1 : 2 : 11 entities Detail

Experiments performed 4 experiments Detail