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BMRB: 34539

6ZV2

TFIIS N-terminal domain (TND) from human PPP1R10

Authors

Veverka, V.

Assembly

Serine/threonine-protein phosphatase 1 regulatory subunit 10

Entity

1. Serine/threonine-protein phosphatase 1 regulatory subunit 10 (polymer), 154 monomers, 17199.80 Da Detail

SNAASMGSGP IDPKELLKGL DSFLNRDGEV KSVDGISKIF SLMKEARKMV SRCTYLNILL QTRSPEILVK FIDVGGYKLL NNWLTYSKTT NNIPLLQQIL LTLQHLPLTV DHLKQNNTAK LVKQLSKSSE DEELRKLASV LVSDWMAVIR SQGS

Formula weight

17199.8 Da

Source organism

Homo sapiens

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 98.1 %, Completeness: 94.9 %, Completeness (bb): 96.1 % Detail

Polymer type: polypeptide(L)

	Total	¹H	¹³C	¹⁵N
All	94.9 % (1748 of 1842)	95.6 % (916 of 958)	95.2 % (677 of 711)	89.6 % (155 of 173)
Backbone	96.1 % (878 of 914)	95.5 % (297 of 311)	97.1 % (441 of 454)	94.0 % (140 of 149)
Sidechain	94.2 % (1012 of 1074)	95.7 % (619 of 647)	93.8 % (378 of 403)	62.5 % (15 of 24)
Aromatic	86.0 % (74 of 86)	97.7 % (42 of 43)	73.2 % (30 of 41)	100.0 % (2 of 2)
Methyl	100.0 % (204 of 204)	100.0 % (102 of 102)	100.0 % (102 of 102)

1. entity 1

SNAASMGSGP IDPKELLKGL DSFLNRDGEV KSVDGISKIF SLMKEARKMV SRCTYLNILL QTRSPEILVK FIDVGGYKLL NNWLTYSKTT NNIPLLQQIL LTLQHLPLTV DHLKQNNTAK LVKQLSKSSE DEELRKLASV LVSDWMAVIR SQGS

Show sample condition

Sample

Solvent system 95% H2O/5% D2O, Pressure 1 atm, Temperature 298 K, pH 7.4, Details 0.7 mM [U-13C; U-15N] PPP1R10, 25 mM [U-2H] TRIS, 200 mM sodium chloride, 1 mM TCEP, 95% H2O/5% D2O

#	Name	Isotope labeling	Concentration
1	PPP1R10	[U-13C; U-15N]	0.7 mM
2	TRIS	[U-2H]	25 mM
3	sodium chloride	natural abundance	200 mM
4	TCEP	natural abundance	1 mM

Release date

2020-08-16

Citation

A ubiquitous disordered protein interaction module orchestrates transcription elongation
Cermakova, K., Demeulemeester, J., Lux, V., Nedomova, M., Goldman, S.R., Smith, E.A., Srb, P., Hexnerova, R., Fabry, M., Madlikova, M., Horejsi, M., De Rijck, J., Debyser, Z., Adelman, K., Hodges, H.C., Veverka, V.
Science (2021), 374, 1113-1121, PubMed 34822292 , DOI 10.1126/science.abe2913 , Abstract

Entries sharing articles BMRB: 6 entries Detail

  BMRB: 34535 released on 2020-08-16
    Title Human TFIIS N-terminal domain (TND)
  BMRB: 34536 released on 2020-08-16
    Title TFIIS N-terminal domain (TND) from human Elongin-A
  BMRB: 34537 released on 2020-08-16
    Title TFIIS N-terminal domain (TND) from human LEDGF/p75
  BMRB: 34538 released on 2020-08-16
    Title TFIIS N-terminal domain (TND) from human IWS1
  BMRB: 34540 released on 2020-08-16
    Title TFIIS N-terminal domain (TND) from human MED26
  BMRB: 34541 released on 2020-07-26
    Title TFIIS N-terminal domain (TND) from human IWS1

Related entities 1. Serine/threonine-protein phosphatase 1 regulatory subunit 10, : 1 : 4 : 14 entities Detail

Interaction partners 1. Serine/threonine-protein phosphatase 1 regulatory subunit 10, : 37 interactors Detail

More details for 37 interactors identified by 13 citations