BMRB: 6896

Solution structure of [Sec2,3,8,12]-ImI

Authors

Armishaw, C.J.

Assembly

Alpha-conotoxin ImI

Entity

1. Alpha-conotoxin ImI (polymer, Thiol state: not present), 12 monomers, 1544.157 Da Detail

GXXSDPRXAW RX

Formula weight

1544.157 Da

Entity Connection

diselenide 2 Detail

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ID	Type	Value order	Atom ID 1	Atom ID 2
1	diselenide	sing	1:SEC2:SEG	1:SEC8:SEG
2	diselenide	sing	1:SEC3:SEG	1:SEC12:SEG

Exptl. method

NMR

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 66.7 %, Completeness: 85.7 %, Completeness (bb): 93.8 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	85.7 % (42 of 49)	85.7 % (42 of 49)
Backbone	93.8 % (15 of 16)	93.8 % (15 of 16)
Sidechain	81.8 % (27 of 33)	81.8 % (27 of 33)
Aromatic	33.3 % (2 of 6)	33.3 % (2 of 6)
Methyl	100.0 % (1 of 1)	100.0 % (1 of 1)

1. Alpha-conotoxin ImI

GXXSDPRXAW RX

Show sample condition

Sample

Pressure 1 atm, Temperature 290 K, pH 3.5

#	Name	Isotope labeling	Type	Concentration
1	Alpha-conotoxin ImI			2 mM
2	D2O			90 %
3	H2O			10 %

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Release date

2005-11-28

Citation

Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists
Armishaw, C.J., Daly, N.L., Nevin, S.T., Adams, D.J., Craik, D.J., Alewood, P.F.
J. Biol. Chem. (2006), 281, 14136-14143, PubMed 16500898 , DOI 10.1074/jbc.M512419200 , Abstract

Entries sharing articles BMRB: 1 entries Detail

Experiments performed 4 experiments Detail