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Found 1 Document (0.803 seconds)

BMRB: 34790

8CIQ

JzTx-34 toxin peptide

Authors

Landon, C., Meudal, H.

Assembly

Mu-theraphotoxin-Cg1a

Entity

1. Mu-theraphotoxin-Cg1a (polymer, Thiol state: all disulfide bound), 35 monomers, 4156.749 Da Detail

ACREWLGGCS KDADCCAHLE CRKKWPYHCV WDWTV

Formula weight

4156.749 Da

Entity Connection

disulfide 3 Detail

ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	1:CYS2:SG	1:CYS16:SG
2	disulfide	sing	1:CYS9:SG	1:CYS21:SG
3	disulfide	sing	1:CYS15:SG	1:CYS29:SG

Source organism

Chilobrachys

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chemcal Shifts

¹H: 232 assignments Detail

ID	Entity ID	Seq ID	Comp ID	Atom ID	Atom type	Val	Ambig. code
1	1	1	ALA	HA	H	4.168	1
2	1	1	ALA	HB1	H	1.575	1
3	1	1	ALA	HB2	H	1.575	1
4	1	1	ALA	HB3	H	1.575	1
5	1	2	CYS	H	H	8.604	1
6	1	2	CYS	HA	H	4.679	1
7	1	2	CYS	HB2	H	2.821	1
8	1	2	CYS	HB3	H	3.143	1
9	1	3	ARG	H	H	9.234	1
10	1	3	ARG	HA	H	4.442	1
11	1	3	ARG	HB2	H	1.656	1
12	1	3	ARG	HB3	H	1.953	1
13	1	3	ARG	HG2	H	1.777	1
14	1	3	ARG	HG3	H	2.041	1
15	1	3	ARG	HD2	H	3.256	1
16	1	3	ARG	HD3	H	3.256	1
17	1	3	ARG	HE	H	7.239	1
18	1	4	GLU	H	H	8.316	1
19	1	4	GLU	HA	H	4.076	1
20	1	4	GLU	HB2	H	2.332	1
21	1	4	GLU	HB3	H	1.894	1
22	1	4	GLU	HG2	H	2.464	1
23	1	4	GLU	HG3	H	2.338	1
24	1	5	TRP	H	H	8.091	1
25	1	5	TRP	HA	H	3.520	1
26	1	5	TRP	HB2	H	2.547	1
27	1	5	TRP	HB3	H	3.043	1
28	1	5	TRP	HD1	H	6.385	1
29	1	5	TRP	HE1	H	10.381	1
30	1	5	TRP	HE3	H	7.515	1
31	1	5	TRP	HZ2	H	7.590	1
32	1	5	TRP	HZ3	H	7.187	1
33	1	5	TRP	HH2	H	7.305	1
34	1	6	LEU	H	H	8.418	1
35	1	6	LEU	HA	H	2.992	1
36	1	6	LEU	HB2	H	1.475	1
37	1	6	LEU	HB3	H	0.904	1
38	1	6	LEU	HG	H	-0.118	1
39	1	6	LEU	HD11	H	-0.541	1
40	1	6	LEU	HD12	H	-0.541	1
41	1	6	LEU	HD13	H	-0.541	1
42	1	6	LEU	HD21	H	-0.118	1
43	1	6	LEU	HD22	H	-0.118	1
44	1	6	LEU	HD23	H	-0.118	1
45	1	7	GLY	H	H	8.995	1
46	1	7	GLY	HA2	H	4.003	1
47	1	7	GLY	HA3	H	3.410	1
48	1	8	GLY	H	H	8.576	1
49	1	8	GLY	HA2	H	3.731	1
50	1	8	GLY	HA3	H	4.217	1
51	1	9	CYS	H	H	7.484	1
52	1	9	CYS	HA	H	4.935	1
53	1	9	CYS	HB2	H	3.213	1
54	1	9	CYS	HB3	H	3.212	1
55	1	10	SER	H	H	9.621	1
56	1	10	SER	HA	H	4.631	1
57	1	10	SER	HB2	H	3.848	1
58	1	10	SER	HB3	H	3.866	1
59	1	11	LYS	H	H	7.988	1
60	1	11	LYS	HA	H	4.646	1
61	1	11	LYS	HB2	H	1.865	1
62	1	11	LYS	HB3	H	1.983	1
63	1	11	LYS	HG2	H	1.456	1
64	1	11	LYS	HG3	H	1.038	1
65	1	11	LYS	HD2	H	1.681	1
66	1	11	LYS	HD3	H	1.595	1
67	1	11	LYS	HE2	H	2.982	1
68	1	11	LYS	HE3	H	2.863	1
69	1	12	ASP	H	H	9.001	1
70	1	12	ASP	HA	H	4.115	1
71	1	12	ASP	HB2	H	2.624	1
72	1	12	ASP	HB3	H	2.907	1
73	1	13	ALA	H	H	8.306	1
74	1	13	ALA	HA	H	4.224	1
75	1	13	ALA	HB1	H	1.376	1
76	1	13	ALA	HB2	H	1.376	1
77	1	13	ALA	HB3	H	1.376	1
78	1	14	ASP	H	H	8.020	1
79	1	14	ASP	HA	H	5.056	1
80	1	14	ASP	HB2	H	3.172	1
81	1	14	ASP	HB3	H	2.800	1
82	1	15	CYS	H	H	7.682	1
83	1	15	CYS	HA	H	4.448	1
84	1	15	CYS	HB2	H	3.006	1
85	1	15	CYS	HB3	H	2.827	1
86	1	16	CYS	H	H	8.999	1
87	1	16	CYS	HA	H	4.639	1
88	1	16	CYS	HB2	H	2.547	1
89	1	16	CYS	HB3	H	3.524	1
90	1	17	ALA	H	H	7.825	1
91	1	17	ALA	HA	H	4.025	1
92	1	17	ALA	HB1	H	1.175	1
93	1	17	ALA	HB2	H	1.175	1
94	1	17	ALA	HB3	H	1.175	1
95	1	18	HIS	H	H	8.577	1
96	1	18	HIS	HA	H	4.275	1
97	1	18	HIS	HB2	H	3.972	1
98	1	18	HIS	HB3	H	3.657	1
99	1	18	HIS	HD2	H	7.258	1
100	1	18	HIS	HE1	H	8.632	1
101	1	19	LEU	H	H	7.709	1
102	1	19	LEU	HA	H	5.164	1
103	1	19	LEU	HB2	H	0.995	1
104	1	19	LEU	HB3	H	2.207	1
105	1	19	LEU	HG	H	1.282	1
106	1	19	LEU	HD11	H	-0.318	1
107	1	19	LEU	HD12	H	-0.318	1
108	1	19	LEU	HD13	H	-0.318	1
109	1	19	LEU	HD21	H	0.592	1
110	1	19	LEU	HD22	H	0.592	1
111	1	19	LEU	HD23	H	0.592	1
112	1	20	GLU	H	H	9.279	1
113	1	20	GLU	HA	H	4.481	1
114	1	20	GLU	HB2	H	1.879	1
115	1	20	GLU	HB3	H	1.978	1
116	1	20	GLU	HG2	H	2.010	1
117	1	20	GLU	HG3	H	2.157	1
118	1	21	CYS	H	H	9.544	1
119	1	21	CYS	HA	H	4.648	1
120	1	21	CYS	HB2	H	2.664	1
121	1	21	CYS	HB3	H	2.553	1
122	1	22	ARG	H	H	8.017	1
123	1	22	ARG	HA	H	4.074	1
124	1	22	ARG	HB2	H	1.791	1
125	1	22	ARG	HB3	H	1.929	1
126	1	22	ARG	HG2	H	1.697	1
127	1	22	ARG	HG3	H	1.697	1
128	1	22	ARG	HD2	H	2.897	1
129	1	22	ARG	HD3	H	3.154	1
130	1	22	ARG	HE	H	7.031	1
131	1	23	LYS	H	H	8.434	1
132	1	23	LYS	HA	H	3.889	1
133	1	23	LYS	HB2	H	1.599	1
134	1	23	LYS	HB3	H	1.762	1
135	1	23	LYS	HG2	H	1.160	1
136	1	23	LYS	HG3	H	1.160	1
137	1	23	LYS	HD2	H	1.417	1
138	1	23	LYS	HD3	H	1.417	1
139	1	23	LYS	HE2	H	2.896	1
140	1	23	LYS	HE3	H	2.896	1
141	1	24	LYS	H	H	7.292	1
142	1	24	LYS	HA	H	4.569	1
143	1	24	LYS	HB2	H	1.558	1
144	1	24	LYS	HB3	H	1.689	1
145	1	24	LYS	HG2	H	1.376	1
146	1	24	LYS	HG3	H	1.376	1
147	1	24	LYS	HD3	H	1.693	1
148	1	24	LYS	HE2	H	3.009	1
149	1	24	LYS	HE3	H	3.009	1
150	1	25	TRP	H	H	8.725	1
151	1	25	TRP	HA	H	3.579	1
152	1	25	TRP	HB2	H	3.079	1
153	1	25	TRP	HB3	H	3.079	1
154	1	25	TRP	HD1	H	7.099	1
155	1	25	TRP	HE1	H	10.171	1
156	1	25	TRP	HE3	H	7.136	1
157	1	25	TRP	HZ2	H	7.464	1
158	1	25	TRP	HZ3	H	7.042	1
159	1	25	TRP	HH2	H	7.196	1
160	1	26	PRO	HA	H	2.826	1
161	1	26	PRO	HB2	H	0.833	1
162	1	26	PRO	HB3	H	1.253	1
163	1	26	PRO	HG2	H	1.132	1
164	1	26	PRO	HG3	H	1.398	1
165	1	26	PRO	HD2	H	3.248	1
166	1	26	PRO	HD3	H	3.011	1
167	1	27	TYR	H	H	7.684	1
168	1	27	TYR	HA	H	4.433	1
169	1	27	TYR	HB2	H	3.168	1
170	1	27	TYR	HB3	H	3.169	1
171	1	27	TYR	HD1	H	7.129	1
172	1	27	TYR	HD2	H	7.129	1
173	1	27	TYR	HE1	H	6.854	1
174	1	27	TYR	HE2	H	6.854	1
175	1	28	HIS	H	H	7.126	1
176	1	28	HIS	HA	H	5.467	1
177	1	28	HIS	HB2	H	2.539	1
178	1	28	HIS	HB3	H	2.877	1
179	1	28	HIS	HD2	H	6.607	1
180	1	28	HIS	HE1	H	8.345	1
181	1	29	CYS	H	H	8.996	1
182	1	29	CYS	HA	H	5.056	1
183	1	29	CYS	HB2	H	2.680	1
184	1	29	CYS	HB3	H	2.899	1
185	1	30	VAL	H	H	9.650	1
186	1	30	VAL	HA	H	4.729	1
187	1	30	VAL	HB	H	2.420	1
188	1	30	VAL	HG11	H	0.814	1
189	1	30	VAL	HG12	H	0.814	1
190	1	30	VAL	HG13	H	0.814	1
191	1	30	VAL	HG21	H	0.935	1
192	1	30	VAL	HG22	H	0.935	1
193	1	30	VAL	HG23	H	0.935	1
194	1	31	TRP	H	H	7.336	1
195	1	31	TRP	HA	H	4.797	1
196	1	31	TRP	HB2	H	2.343	1
197	1	31	TRP	HB3	H	2.194	1
198	1	31	TRP	HD1	H	6.769	1
199	1	31	TRP	HE1	H	8.291	1
200	1	31	TRP	HE3	H	7.618	1
201	1	31	TRP	HZ2	H	7.042	1
202	1	31	TRP	HZ3	H	7.114	1
203	1	31	TRP	HH2	H	7.182	1
204	1	32	ASP	H	H	8.906	1
205	1	32	ASP	HA	H	4.362	1
206	1	32	ASP	HB2	H	2.879	1
207	1	32	ASP	HB3	H	2.433	1
208	1	33	TRP	H	H	7.433	1
209	1	33	TRP	HA	H	4.816	1
210	1	33	TRP	HB2	H	3.469	1
211	1	33	TRP	HB3	H	3.318	1
212	1	33	TRP	HD1	H	7.229	1
213	1	33	TRP	HE1	H	9.835	1
214	1	33	TRP	HE3	H	7.659	1
215	1	33	TRP	HZ2	H	6.760	1
216	1	33	TRP	HZ3	H	6.992	1
217	1	33	TRP	HH2	H	6.708	1
218	1	34	THR	H	H	7.914	1
219	1	34	THR	HA	H	4.331	1
220	1	34	THR	HB	H	4.218	1
221	1	34	THR	HG21	H	0.991	1
222	1	34	THR	HG22	H	0.991	1
223	1	34	THR	HG23	H	0.991	1
224	1	35	VAL	H	H	7.568	1
225	1	35	VAL	HA	H	3.999	1
226	1	35	VAL	HB	H	2.059	1
227	1	35	VAL	HG11	H	0.854	1
228	1	35	VAL	HG12	H	0.854	1
229	1	35	VAL	HG13	H	0.854	1
230	1	35	VAL	HG21	H	0.850	1
231	1	35	VAL	HG22	H	0.850	1
232	1	35	VAL	HG23	H	0.850	1

Release date

2023-03-29

Citation

Structure-function relationship of new peptides activating human Na(v)1.1
Lopez, L., De Waard, S., Meudal, H., Caumes, C., Khakh, K., Peigneur, S., Oliveira-Mendes, B., Lin, S., De Waele, J., Montnach, J., Cestele, S., Tessier, A., Johnson, J.P., Mantegazza, M., Tytgat, J., Cohen, C., Beroud, R., Bosmans, F., Landon, C., De Waard, M.
Biomed. Pharmacother. (2023), 165, 115173-115173, PubMed 37453200 , DOI 10.1016/j.biopha.2023.115173 , Abstract

Entries sharing articles BMRB: 5 entries Detail

  BMRB: 34791 released on 2023-09-14
    Title JzTx-34 toxin peptide H18A mutant
  BMRB: 34794 released on 2023-09-14
    Title JzTx-34 toxin peptide W31A mutant
  BMRB: 34792 released on 2023-03-29
    Title JzTx-34 toxin peptide E20A mutant
  BMRB: 34793 released on 2023-03-29
    Title JzTx-34 toxin peptide W25A mutant
  BMRB: 34795 released on 2023-03-29
    Title JzTx-34 toxin peptide W33A mutant

Related entities 1. Mu-theraphotoxin-Cg1a, : 1 : 1 : 5 : 100 entities Detail

Experiments performed 5 experiments Detail

#	Name	Isotope labeling	Type	Concentration
1	JzTx-34 wild type	natural abundance		0.1 mM

#	Name	Isotope labeling	Type	Concentration
1	JzTx-34 wild type	natural abundance		0.1 mM

#	Name	Isotope labeling	Type	Concentration
1	JzTx-34 wild type	natural abundance		0.1 mM

#	Name	Isotope labeling	Type	Concentration
1	JzTx-34 wild type	natural abundance		0.1 mM

#	Name	Isotope labeling	Type	Concentration
1	JzTx-34 wild type	natural abundance		0.1 mM

nullKeywords JZTX-34 WILD TYPE PEPTIDE TOXIN hNav1.1 channel sodium channel, TOXIN

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Found 1 Document (0.803 seconds)

BMRB: 34790

Entries sharing articles BMRB: 5 entries Detail

Related entities 1. Mu-theraphotoxin-Cg1a, : 1 : 1 : 5 : 100 entities Detail

Experiments performed 5 experiments Detail

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