BMRBj - BMREntryMaster

Found 1 Document (3.246 seconds)

BMRB: 34793

8CJR

JzTx-34 toxin peptide W25A mutant

Authors

Landon, C., Meudal, H.

Assembly

Mu-theraphotoxin-Cg1a

Entity

1. Mu-theraphotoxin-Cg1a (polymer, Thiol state: all disulfide bound), 35 monomers, 4041.617 Da Detail

ACREWLGGCS KDADCCAHLE CRKKAPYHCV WDWTV

Formula weight

4041.617 Da

Entity Connection

disulfide 3 Detail

ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	1:CYS2:SG	1:CYS16:SG
2	disulfide	sing	1:CYS9:SG	1:CYS21:SG
3	disulfide	sing	1:CYS15:SG	1:CYS29:SG

Source organism

Chilobrachys

Exptl. method

solution NMR

Data set

assigned_chemical_shifts

Chemcal Shifts

¹H: 228, ¹⁵N: 32 assignments Detail

ID	Entity ID	Seq ID	Comp ID	Atom ID	Atom type	Val	Ambig. code
1	1	1	ALA	HA	H	4.175	1
2	1	1	ALA	HB1	H	1.576	1
3	1	1	ALA	HB2	H	1.576	1
4	1	1	ALA	HB3	H	1.576	1
5	1	2	CYS	H	H	8.610	1
6	1	2	CYS	HA	H	4.680	1
7	1	2	CYS	HB2	H	3.146	1
8	1	2	CYS	HB3	H	2.826	1
9	1	2	CYS	N	N	117.538	1
10	1	3	ARG	H	H	9.245	1
11	1	3	ARG	HA	H	4.463	1
12	1	3	ARG	HB2	H	1.975	1
13	1	3	ARG	HB3	H	1.675	1
14	1	3	ARG	HG2	H	2.059	1
15	1	3	ARG	HG3	H	1.797	1
16	1	3	ARG	HD2	H	3.270	1
17	1	3	ARG	HD3	H	3.270	1
18	1	3	ARG	HE	H	7.257	1
19	1	3	ARG	N	N	121.771	1
20	1	4	GLU	H	H	8.323	1
21	1	4	GLU	HA	H	4.087	1
22	1	4	GLU	HB2	H	2.337	1
23	1	4	GLU	HB3	H	1.897	1
24	1	4	GLU	HG2	H	2.464	1
25	1	4	GLU	HG3	H	2.337	1
26	1	4	GLU	N	N	121.366	1
27	1	5	TRP	H	H	8.106	1
28	1	5	TRP	HA	H	3.542	1
29	1	5	TRP	HB2	H	2.559	1
30	1	5	TRP	HB3	H	3.054	1
31	1	5	TRP	HD1	H	6.420	1
32	1	5	TRP	HE1	H	10.406	1
33	1	5	TRP	HE3	H	7.537	1
34	1	5	TRP	HZ2	H	7.604	1
35	1	5	TRP	HZ3	H	7.197	1
36	1	5	TRP	HH2	H	7.312	1
37	1	5	TRP	N	N	119.914	1
38	1	6	LEU	H	H	8.450	1
39	1	6	LEU	HA	H	2.999	1
40	1	6	LEU	HB2	H	0.923	1
41	1	6	LEU	HB3	H	1.489	1
42	1	6	LEU	HG	H	-0.116	1
43	1	6	LEU	HD11	H	-0.116	1
44	1	6	LEU	HD12	H	-0.116	1
45	1	6	LEU	HD13	H	-0.116	1
46	1	6	LEU	HD21	H	-0.527	1
47	1	6	LEU	HD22	H	-0.527	1
48	1	6	LEU	HD23	H	-0.527	1
49	1	6	LEU	N	N	121.647	1
50	1	7	GLY	H	H	9.025	1
51	1	7	GLY	HA2	H	4.049	1
52	1	7	GLY	HA3	H	3.437	1
53	1	7	GLY	N	N	110.162	1
54	1	8	GLY	H	H	8.619	1
55	1	8	GLY	HA2	H	3.790	1
56	1	8	GLY	HA3	H	4.286	1
57	1	8	GLY	N	N	109.572	1
58	1	9	CYS	H	H	7.571	1
59	1	9	CYS	HA	H	4.950	1
60	1	9	CYS	HB2	H	3.238	1
61	1	9	CYS	HB3	H	3.238	1
62	1	9	CYS	N	N	114.623	1
63	1	10	SER	H	H	9.596	1
64	1	10	SER	HA	H	4.577	1
65	1	10	SER	HB2	H	3.827	1
66	1	10	SER	HB3	H	3.784	1
67	1	10	SER	N	N	112.714	1
68	1	11	LYS	H	H	7.994	1
69	1	11	LYS	HA	H	4.658	1
70	1	11	LYS	HB2	H	1.979	1
71	1	11	LYS	HB3	H	1.861	1
72	1	11	LYS	HG2	H	1.037	1
73	1	11	LYS	HG3	H	1.452	1
74	1	11	LYS	HD2	H	1.682	1
75	1	11	LYS	HD3	H	1.592	1
76	1	11	LYS	HE2	H	2.974	1
77	1	11	LYS	HE3	H	2.849	1
78	1	11	LYS	N	N	119.321	1
79	1	12	ASP	H	H	9.014	1
80	1	12	ASP	HA	H	4.138	1
81	1	12	ASP	HB2	H	2.925	1
82	1	12	ASP	HB3	H	2.632	1
83	1	12	ASP	N	N	124.044	1
84	1	13	ALA	H	H	8.310	1
85	1	13	ALA	HA	H	4.231	1
86	1	13	ALA	HB1	H	1.379	1
87	1	13	ALA	HB2	H	1.379	1
88	1	13	ALA	HB3	H	1.379	1
89	1	13	ALA	N	N	117.805	1
90	1	14	ASP	H	H	8.020	1
91	1	14	ASP	HA	H	5.076	1
92	1	14	ASP	HB2	H	2.803	1
93	1	14	ASP	HB3	H	3.184	1
94	1	14	ASP	N	N	117.834	1
95	1	15	CYS	H	H	7.681	1
96	1	15	CYS	HA	H	4.454	1
97	1	15	CYS	HB2	H	2.838	1
98	1	15	CYS	HB3	H	3.016	1
99	1	15	CYS	N	N	116.108	1
100	1	16	CYS	H	H	9.024	1
101	1	16	CYS	HA	H	4.647	1
102	1	16	CYS	HB2	H	3.537	1
103	1	16	CYS	HB3	H	2.561	1
104	1	16	CYS	N	N	119.291	1
105	1	17	ALA	H	H	7.834	1
106	1	17	ALA	HA	H	4.033	1
107	1	17	ALA	HB1	H	1.182	1
108	1	17	ALA	HB2	H	1.182	1
109	1	17	ALA	HB3	H	1.182	1
110	1	17	ALA	N	N	118.979	1
111	1	18	HIS	H	H	8.578	1
112	1	18	HIS	HA	H	4.284	1
113	1	18	HIS	HB2	H	3.644	1
114	1	18	HIS	HB3	H	3.963	1
115	1	18	HIS	HD2	H	7.256	1
116	1	18	HIS	HE1	H	8.629	1
117	1	18	HIS	N	N	109.818	1
118	1	19	LEU	H	H	7.722	1
119	1	19	LEU	HA	H	5.181	1
120	1	19	LEU	HB2	H	1.014	1
121	1	19	LEU	HB3	H	2.218	1
122	1	19	LEU	HG	H	1.295	1
123	1	19	LEU	HD11	H	0.608	1
124	1	19	LEU	HD12	H	0.608	1
125	1	19	LEU	HD13	H	0.608	1
126	1	19	LEU	HD21	H	-0.294	1
127	1	19	LEU	HD22	H	-0.294	1
128	1	19	LEU	HD23	H	-0.294	1
129	1	19	LEU	N	N	118.073	1
130	1	20	GLU	H	H	9.314	1
131	1	20	GLU	HA	H	4.498	1
132	1	20	GLU	HB2	H	1.899	1
133	1	20	GLU	HB3	H	1.985	1
134	1	20	GLU	HG2	H	1.990	1
135	1	20	GLU	HG3	H	2.145	1
136	1	20	GLU	N	N	117.131	1
137	1	21	CYS	H	H	9.547	1
138	1	21	CYS	HA	H	4.706	1
139	1	21	CYS	HB2	H	2.672	1
140	1	21	CYS	HB3	H	2.570	1
141	1	21	CYS	N	N	122.371	1
142	1	22	ARG	H	H	7.929	1
143	1	22	ARG	HA	H	4.052	1
144	1	22	ARG	HB2	H	2.030	1
145	1	22	ARG	HB3	H	1.804	1
146	1	22	ARG	HG2	H	1.749	1
147	1	22	ARG	HG3	H	1.749	1
148	1	22	ARG	HD2	H	3.182	1
149	1	22	ARG	HD3	H	2.919	1
150	1	22	ARG	HE	H	7.014	1
151	1	22	ARG	N	N	130.156	1
152	1	23	LYS	H	H	8.376	1
153	1	23	LYS	HA	H	3.918	1
154	1	23	LYS	HB2	H	1.605	1
155	1	23	LYS	HB3	H	1.836	1
156	1	23	LYS	HG2	H	1.243	1
157	1	23	LYS	HG3	H	1.462	1
158	1	23	LYS	HD2	H	1.532	1
159	1	23	LYS	HD3	H	1.532	1
160	1	23	LYS	HE2	H	2.962	1
161	1	23	LYS	HE3	H	2.962	1
162	1	23	LYS	N	N	122.163	1
163	1	24	LYS	H	H	7.282	1
164	1	24	LYS	HA	H	4.430	1
165	1	24	LYS	HB2	H	1.652	1
166	1	24	LYS	HB3	H	1.517	1
167	1	24	LYS	HG2	H	1.326	1
168	1	24	LYS	HG3	H	1.326	1
169	1	24	LYS	HD2	H	1.649	1
170	1	24	LYS	HD3	H	1.648	1
171	1	24	LYS	HE2	H	2.965	1
172	1	24	LYS	HE3	H	2.965	1
173	1	24	LYS	N	N	120.127	1
174	1	25	ALA	H	H	8.347	1
175	1	25	ALA	HA	H	3.319	1
176	1	25	ALA	HB1	H	1.094	1
177	1	25	ALA	HB2	H	1.094	1
178	1	25	ALA	HB3	H	1.094	1
179	1	25	ALA	N	N	125.520	1
180	1	26	PRO	HA	H	4.244	1
181	1	26	PRO	HB2	H	1.784	1
182	1	26	PRO	HB3	H	2.202	1
183	1	26	PRO	HG2	H	1.734	1
184	1	26	PRO	HG3	H	1.851	1
185	1	26	PRO	HD2	H	3.368	1
186	1	26	PRO	HD3	H	3.474	1
187	1	27	TYR	H	H	8.490	1
188	1	27	TYR	HA	H	4.390	1
189	1	27	TYR	HB2	H	3.125	1
190	1	27	TYR	HB3	H	3.242	1
191	1	27	TYR	HD1	H	7.098	1
192	1	27	TYR	HD2	H	7.098	1
193	1	27	TYR	HE1	H	6.640	1
194	1	27	TYR	HE2	H	6.640	1
195	1	27	TYR	N	N	124.471	1
196	1	28	HIS	H	H	7.120	1
197	1	28	HIS	HA	H	5.542	1
198	1	28	HIS	HB2	H	2.971	1
199	1	28	HIS	HB3	H	2.600	1
200	1	28	HIS	HD2	H	6.665	1
201	1	28	HIS	HE1	H	8.375	1
202	1	28	HIS	N	N	117.902	1
203	1	29	CYS	H	H	9.036	1
204	1	29	CYS	HA	H	5.075	1
205	1	29	CYS	HB2	H	2.702	1
206	1	29	CYS	HB3	H	2.939	1
207	1	29	CYS	N	N	120.723	1
208	1	30	VAL	H	H	9.693	1
209	1	30	VAL	HA	H	4.755	1
210	1	30	VAL	HB	H	2.453	1
211	1	30	VAL	HG11	H	0.990	1
212	1	30	VAL	HG12	H	0.990	1
213	1	30	VAL	HG13	H	0.990	1
214	1	30	VAL	HG21	H	0.839	1
215	1	30	VAL	HG22	H	0.839	1
216	1	30	VAL	HG23	H	0.839	1
217	1	31	TRP	H	H	7.383	1
218	1	31	TRP	HA	H	4.812	1
219	1	31	TRP	HB2	H	2.394	1
220	1	31	TRP	HB3	H	2.268	1
221	1	31	TRP	HD1	H	6.795	1
222	1	31	TRP	HE1	H	8.283	1
223	1	31	TRP	HE3	H	7.639	1
224	1	31	TRP	HZ2	H	7.044	1
225	1	31	TRP	HZ3	H	7.112	1
226	1	31	TRP	HH2	H	7.186	1
227	1	31	TRP	N	N	121.033	1
228	1	32	ASP	H	H	8.912	1
229	1	32	ASP	HA	H	4.387	1
230	1	32	ASP	HB2	H	2.880	1
231	1	32	ASP	HB3	H	2.429	1
232	1	32	ASP	N	N	122.283	1
233	1	33	TRP	H	H	7.497	1
234	1	33	TRP	HA	H	4.813	1
235	1	33	TRP	HB2	H	3.471	1
236	1	33	TRP	HB3	H	3.327	1
237	1	33	TRP	HD1	H	7.248	1
238	1	33	TRP	HE1	H	9.844	1
239	1	33	TRP	HE3	H	7.664	1
240	1	33	TRP	HZ2	H	6.793	1
241	1	33	TRP	HZ3	H	6.999	1
242	1	33	TRP	HH2	H	6.723	1
243	1	33	TRP	N	N	117.031	1
244	1	34	THR	H	H	7.959	1
245	1	34	THR	HA	H	4.313	1
246	1	34	THR	HB	H	4.216	1
247	1	34	THR	HG21	H	0.969	1
248	1	34	THR	HG22	H	0.969	1
249	1	34	THR	HG23	H	0.969	1
250	1	34	THR	N	N	115.158	1
251	1	35	VAL	H	H	7.517	1
252	1	35	VAL	HA	H	3.993	1
253	1	35	VAL	HB	H	2.053	1
254	1	35	VAL	HG11	H	0.846	1
255	1	35	VAL	HG12	H	0.846	1
256	1	35	VAL	HG13	H	0.846	1
257	1	35	VAL	HG21	H	0.845	1
258	1	35	VAL	HG22	H	0.845	1
259	1	35	VAL	HG23	H	0.845	1
260	1	35	VAL	N	N	125.921	1

Release date

2023-03-29

Citation

Structure-function relationship of new peptides activating human Na(v)1.1
Lopez, L., De Waard, S., Meudal, H., Caumes, C., Khakh, K., Peigneur, S., Oliveira-Mendes, B., Lin, S., De Waele, J., Montnach, J., Cestele, S., Tessier, A., Johnson, J.P., Mantegazza, M., Tytgat, J., Cohen, C., Beroud, R., Bosmans, F., Landon, C., De Waard, M.
Biomed. Pharmacother. (2023), 165, 115173-115173, PubMed 37453200 , DOI 10.1016/j.biopha.2023.115173 , Abstract

Entries sharing articles BMRB: 5 entries Detail

  BMRB: 34791 released on 2023-09-14
    Title JzTx-34 toxin peptide H18A mutant
  BMRB: 34794 released on 2023-09-14
    Title JzTx-34 toxin peptide W31A mutant
  BMRB: 34790 released on 2023-03-29
    Title JzTx-34 toxin peptide
  BMRB: 34792 released on 2023-03-29
    Title JzTx-34 toxin peptide E20A mutant
  BMRB: 34795 released on 2023-03-29
    Title JzTx-34 toxin peptide W33A mutant

Related entities 1. Mu-theraphotoxin-Cg1a, : 1 : 6 : 91 entities Detail

Experiments performed 5 experiments Detail

#	Name	Isotope labeling	Type	Concentration
1	JzTx-34 W25A mutant (Jingzhaotoxin-34)	natural abundance		0.1 mM

#	Name	Isotope labeling	Type	Concentration
1	JzTx-34 W25A mutant (Jingzhaotoxin-34)	natural abundance		0.1 mM

#	Name	Isotope labeling	Type	Concentration
1	JzTx-34 W25A mutant (Jingzhaotoxin-34)	natural abundance		0.1 mM

#	Name	Isotope labeling	Type	Concentration
1	JzTx-34 W25A mutant (Jingzhaotoxin-34)	natural abundance		0.1 mM

#	Name	Isotope labeling	Type	Concentration
1	JzTx-34 W25A mutant (Jingzhaotoxin-34)	natural abundance		0.1 mM

nullKeywords JZTX-34 PEPTIDE TOXIN, TOXIN, hNav1.1 channel sodium channel

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Found 1 Document (3.246 seconds)

BMRB: 34793

Entries sharing articles BMRB: 5 entries Detail

Related entities 1. Mu-theraphotoxin-Cg1a, : 1 : 6 : 91 entities Detail

Experiments performed 5 experiments Detail

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